2024
Endometrial stromal cell signaling and microRNA exosome content in women with adenomyosis
Zipponi M, Cacciottola L, Camboni A, Stratopoulou C, Taylor H, Dolmans M. Endometrial stromal cell signaling and microRNA exosome content in women with adenomyosis. Molecular Human Reproduction 2024, 31: gaae044. PMID: 39673794, DOI: 10.1093/molehr/gaae044.Peer-Reviewed Original ResearchStromal cell signalsMenstrual phaseHealthy subjectsPresence of endometrial glandsPathogenesis of adenomyosisCompared to controlsEndometrial biopsyEndometrial glandsEutopic endometriumStromal compartmentAdenomyosisAdenomyosis developmentMolecular mechanismsCell signalingLesion establishmentStromal cellsNanoparticle tracking analysisFlow cytometryEpithelial glandsParacrine signalingQuality of lifeSecreted exosomesIntercellular communicationExosomal contentsReproductive health
2017
Predictive Biomarkers May allow Precision Therapy of Endometriosis
Hou Z, Mamillapalli R, Taylor HS. Predictive Biomarkers May allow Precision Therapy of Endometriosis. Journal Of Endometriosis And Pelvic Pain Disorders 2017, 9: 279-285. PMID: 35441077, PMCID: PMC9014966, DOI: 10.5301/jeppd.5000311.Peer-Reviewed Original ResearchMedroxyprogesterone acetatePredictive biomarkersProgesterone receptorEstrogen receptorPrecision therapyEutopic endometrial stromal cellsSelective estrogen receptor modulatorsEffect of bazedoxifeneEndometrial stromal cellsEstrogen receptor modulatorsPathogenesis of endometriosisPrimary eutopic endometrial stromal cellsCommon molecular targetsPRA/BPersonalized medicine approachReverse transcriptase-polymerase chain reaction analysisTranscriptase-polymerase chain reaction analysisBaseline expression levelsPelvic painEndometrial biopsyEndometriosis therapySevere endometriosisProgestin resistanceEndometriosis patientsPR expression
2012
Progesterone-dependent regulation of endometrial cannabinoid receptor type 1 (CB1-R) expression is disrupted in women with endometriosis and in isolated stromal cells exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)
Resuehr D, Glore DR, Taylor HS, Bruner-Tran KL, Osteen KG. Progesterone-dependent regulation of endometrial cannabinoid receptor type 1 (CB1-R) expression is disrupted in women with endometriosis and in isolated stromal cells exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Fertility And Sterility 2012, 98: 948-956.e1. PMID: 22789143, PMCID: PMC3462249, DOI: 10.1016/j.fertnstert.2012.06.009.Peer-Reviewed Original ResearchConceptsEndometrial stromal cellsEndometrial tissueStromal cellsCannabinoid receptor type 1 expressionProgesterone-dominated secretory phaseMRNA expressionAnti-inflammatory actionMessenger RNATetrachlorodibenzo-p-dioxin (TCDD) exposureHuman endometrial tissueProgesterone receptor antagonistType 1 expressionSteroid-induced expressionProgesterone-dependent regulationEndometrial biopsyReceptor antagonistCannabinoid signalingHuman endometriumMedical CenterMAIN OUTCOMESecretory phaseControl donorsEndometriosisDifferentiation-related expressionExposure disruptsAssessment of Uterine Receptivity
Cakmak H, Taylor H. Assessment of Uterine Receptivity. 2012, 559-566. DOI: 10.1007/978-1-4419-1780-5_62.Peer-Reviewed Original ResearchEndometrial receptivityUterine receptivityPregnancy outcomesPolycystic ovary syndromeFirst-line investigationFirst-line modalityPerfect diagnostic toolIVF cyclesEndometrial biopsyEndometrial polypsOvary syndromeSubfertile womenEndometrial pathologyEndometrial liningGynecologic diseaseHistological datingGynecologic conditionsSuccessful pregnancyPregnancy rateSonographic parametersGold standardReproductive technologiesPregnancyUltrasonographyDiagnostic tool
2011
MicroRNA 135 Regulates HOXA10 Expression in Endometriosis
Petracco R, Grechukhina O, Popkhadze S, Massasa E, Zhou Y, Taylor HS. MicroRNA 135 Regulates HOXA10 Expression in Endometriosis. The Journal Of Clinical Endocrinology & Metabolism 2011, 96: e1925-e1933. PMID: 21956427, PMCID: PMC3232619, DOI: 10.1210/jc.2011-1231.Peer-Reviewed Original ResearchConceptsEndometrium of womenHOXA10 expressionHOXA10 regulationB expressionProliferative phaseEndometrial stromal cellsUniversity Medical CenterRegulation of HOXA10Time of ovulationMicroRNA-135Endometrial biopsyEndometrial receptivityMCF-7 cellsEndometrial samplesMenstrual cycleLuteal phaseMedical CenterSex steroidsStudy interventionEndometriosisSecretory phaseHOXA10 mRNAMicroRNA-135aStromal cellsEndometrium
2010
Endothelin Type A Receptor (ETA) Expression Is Regulated by HOXA10 in Human Endometrial Stromal Cells
Penna IA, Du H, Kallen AN, Taylor HS. Endothelin Type A Receptor (ETA) Expression Is Regulated by HOXA10 in Human Endometrial Stromal Cells. Reproductive Sciences 2010, 17: 471-476. PMID: 20371740, PMCID: PMC3107845, DOI: 10.1177/1933719110361961.Peer-Reviewed Original ResearchConceptsHuman endometrial stromal cell lineEndometrial stromal cellsEndometrial stromal cell lineFirst trimester decidual cellsStromal cellsHuman endometrial stromal cellsEndometrial epithelial cell lineHuman endometrial epithelial cell lineFirst trimester deciduaVascular smooth muscle cellsReverse transcriptase-polymerase chain reactionQuantitative reverse transcriptase-polymerase chain reactionTranscriptase-polymerase chain reactionSmooth muscle cellsCell linesStromal cell growthG protein-coupled receptorsReproductive-age individualsEndometrial biopsyProtein-coupled receptorsEndometrial receptivityNormal endometriumDecidual samplesElective terminationEpithelial cell line
2008
Calpain5 expression is decreased in endometriosis and regulated by HOXA10 in human endometrial cells
Penna I, Du H, Ferriani R, Taylor HS. Calpain5 expression is decreased in endometriosis and regulated by HOXA10 in human endometrial cells. Molecular Human Reproduction 2008, 14: 613-618. PMID: 18829447, PMCID: PMC2734161, DOI: 10.1093/molehr/gan055.Peer-Reviewed Original ResearchConceptsEndometrial cellsGlandular cellsDevelopment of endometriosisHuman endometrial cellsExpression of HOXA10Real-time RT-PCRQuantitative real-time RT-PCRHOXA10 siRNAEndometrial biopsyEpithelial cell lineDecidual samplesEutopic endometriumMenstrual cyclePregnancy terminationEndometriosisFertile controlsHOXA10 expressionDecreased expressionRT-PCRProtein expressionRespective controlsHOXA10BiopsyCell linesAberrant regulationSubmucosal uterine leiomyomas have a global effect on molecular determinants of endometrial receptivity
Rackow BW, Taylor HS. Submucosal uterine leiomyomas have a global effect on molecular determinants of endometrial receptivity. Fertility And Sterility 2008, 93: 2027-2034. PMID: 18555231, PMCID: PMC3107853, DOI: 10.1016/j.fertnstert.2008.03.029.Peer-Reviewed Original ResearchMeSH KeywordsAdultBiomarkers, TumorCase-Control StudiesEmbryo ImplantationEndometriumFemaleGene Expression Regulation, NeoplasticHomeobox A10 ProteinsHomeodomain ProteinsHumansInfertility, FemaleKruppel-Like Transcription FactorsLeiomyomaLeukemia Inhibitory FactorMiddle AgedMucous MembranePrognosisUterine NeoplasmsConceptsReal-time reverse transcriptase-polymerase chain reactionSubmucosal myomasEndometrial receptivityUterine leiomyomaMRNA expressionEndometrial HOXA10 expressionSubmucosal uterine leiomyomasLIF mRNA expressionReproductive-aged womenTime of surgeryCase-control studyReverse transcriptase-polymerase chain reactionHOXA10 protein expressionQuantitative real-time reverse transcriptase-polymerase chain reactionUniversity Medical CenterTranscriptase-polymerase chain reactionMessenger RNA expressionReal-time RT-PCREndometrial samplingPrimary endpointEndometrial biopsyUterine myomaIntramural myomasMedical CenterReproductive dysfunctionGnRH antagonists may affect endometrial receptivity
Rackow BW, Kliman HJ, Taylor HS. GnRH antagonists may affect endometrial receptivity. Fertility And Sterility 2008, 89: 1234-1239. PMID: 18410932, PMCID: PMC2699407, DOI: 10.1016/j.fertnstert.2007.04.060.Peer-Reviewed Original ResearchConceptsGnRH antagonistEndometrial stromal cellsEndometrial receptivityHOXA10 protein expressionHOXA10 expressionGnRH agonistControl subjectsProspective case-control studyStromal cellsEndometrial HOXA10 expressionPipelle endometrial biopsyProtein expressionSpontaneous LH surgeCase-control studyAcademic medical centerNatural cycleOvarian hyperstimulationRecombinant FSHEndometrial biopsyHCG administrationUntreated cyclesEndometrial glandsLH surgeMedical CenterMAIN OUTCOME
2004
Hormonal regulation of implantation
Kodaman PH, Taylor HS. Hormonal regulation of implantation. Obstetrics And Gynecology Clinics Of North America 2004, 31: 745-766. PMID: 15550333, DOI: 10.1016/j.ogc.2004.08.008.Peer-Reviewed Original ResearchConceptsEndometrial receptivityLuteal phase endometrial biopsyPhase endometrial biopsiesPolycystic ovary syndromeNormal hormone levelsFemale sex steroidsOvarian hyperstimulationEndometrial histologyEndometrial biopsyOvary syndromeEstrogen levelsElevated androgensHormone levelsReceptive endometriumCell adhesion moleculeSex steroidsMolecular mediatorsSuccessful implantationAnalysis of markersGrowth factorAdhesion moleculesPeptide hormonesHormonal regulationEndometriumImplantationEndometrial Cells Derived From Donor Stem Cells in Bone Marrow Transplant Recipients
Taylor HS. Endometrial Cells Derived From Donor Stem Cells in Bone Marrow Transplant Recipients. JAMA 2004, 292: 81-85. PMID: 15238594, DOI: 10.1001/jama.292.1.81.Peer-Reviewed Original ResearchConceptsBone marrow transplant recipientsMarrow transplant recipientsEndometrial cellsTransplant recipientsHLA typesDonor-derived bone marrow cellsBone marrow-derived cellsEndometrial biopsy samplesBone marrow recipientsHealthy control womenMarrow-derived cellsStem cellsReverse transcription-polymerase chain reactionEndometrial stem cellsBone marrow donorsTranscription-polymerase chain reactionDonor stem cellsBone marrow cellsExtrauterine originHLA mismatchesEndometrial biopsyMarrow recipientsControl womenHLA expressionEndometrial samples
2003
Endometrial HOXA10 expression after controlled ovarian hyperstimulation with recombinant follicle-stimulating hormone
Taylor HS, Daftary GS, Selam B. Endometrial HOXA10 expression after controlled ovarian hyperstimulation with recombinant follicle-stimulating hormone. Fertility And Sterility 2003, 80: 839-843. PMID: 14505762, DOI: 10.1016/s0015-0282(03)00985-3.Peer-Reviewed Original ResearchMeSH KeywordsAdultEmbryo ImplantationEndometriumEstradiolFemaleFertility Agents, FemaleFollicle Stimulating HormoneGonadotropin-Releasing HormoneHomeobox A10 ProteinsHomeodomain ProteinsHormone AntagonistsHumansLeuprolideOvulation InductionProspective StudiesRecombinant ProteinsReverse Transcriptase Polymerase Chain ReactionRNATumor Cells, CulturedConceptsEndometrial HOXA10 expressionOvarian hyperstimulationRecombinant FSHReverse transcriptase-polymerase chain reactionGnRH agonistGnRH antagonistHOXA10 expressionFertile controlsRecombinant follicle-stimulating hormoneCycle day 21Pipelle endometrial biopsyFollicle-stimulating hormoneQuantitative reverse transcriptase-polymerase chain reactionTranscriptase-polymerase chain reactionAcademic medical centerDose-dependent mannerEndometrial biopsyEndometrial receptivityProspective studyIshikawa cellsMedical CenterHyperstimulationMAIN OUTCOMEFSHDay 21Regulation of HOXA-10 Expression by Testosterone in Vitro and in the Endometrium of Patients with Polycystic Ovary Syndrome
Cermik D, Selam B, Taylor HS. Regulation of HOXA-10 Expression by Testosterone in Vitro and in the Endometrium of Patients with Polycystic Ovary Syndrome. The Journal Of Clinical Endocrinology & Metabolism 2003, 88: 238-243. PMID: 12519859, DOI: 10.1210/jc.2002-021072.Peer-Reviewed Original ResearchConceptsPolycystic ovary syndromeOvary syndromeHOXA10 expressionEndometrium of patientsHOXA-10 expressionUterine HOXA10 expressionPregnancy loss rateReproductive-age womenAdverse reproductive outcomesExpression of HOXA10Ovarian androgensOvulatory disordersEndometrial biopsyEndometrial receptivityUterine dysfunctionAndrogen productionPregnancy rateReproductive outcomesTestosterone effectsHOXA10 mRNATestosteroneWomenEndometriumSyndromeHOXA10
1998
Interleukin-8 in the Human Endometrium1
Arici A, Seli E, Senturk L, Gutierrez L, Oral E, Taylor H. Interleukin-8 in the Human Endometrium1. The Journal Of Clinical Endocrinology & Metabolism 1998, 83: 1783-1787. PMID: 9589693, DOI: 10.1210/jcem.83.5.4754.Peer-Reviewed Original ResearchConceptsIL-8 messenger ribonucleic acidInterleukin-8Menstrual cycleMessenger ribonucleic acidHuman endometriumMenstrual historyT cell chemotactic activityIL-8 mRNA levelsWoman's menstrual historyImmunoreactive IL-8IL-8 antibodyIL-8 expressionIL-8 proteinEndometrial biopsyEndometrial diseaseEndometrial tissueSex hormonesHuman uterusSurface epitheliumChemotactic activityEndometriumFrozen sectionsStromal cellsLate secretoryGlandular cells
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply