2025
The role of long non-coding ribonucleic acid HOXA11-AS in endometriosis therapy
Mamillapalli R, Gawde N, Fay M, Atwani R, Moridi I, Taylor H. The role of long non-coding ribonucleic acid HOXA11-AS in endometriosis therapy. Reproductive Biology And Endocrinology 2025, 23: 83. PMID: 40457415, PMCID: PMC12128536, DOI: 10.1186/s12958-025-01420-0.Peer-Reviewed Original ResearchConceptsHOXA11-ASHOXA11-AS expressionEutopic endometriumLong non-coding RNAsEctopic endometriotic lesionsEndometriotic cell linesInvasion of endometriosisEndometrial stromal cellsReal-time polymerase chain reactionNon-coding RNAsEndometriotic lesionsEndometriosis therapyEndometriosis patientsNormal endometriumProgestin responsivenessEndometrial developmentTreatment responsePolymerase chain reactionQuantitative real-time polymerase chain reactionEndometriosisEndometriosis treatmentMethodsTissue samplesStromal cellsPotential target genesEndometrium
2015
The Role of Hox Genes in Female Reproductive Tract Development, Adult Function, and Fertility
Du H, Taylor HS. The Role of Hox Genes in Female Reproductive Tract Development, Adult Function, and Fertility. Cold Spring Harbor Perspectives In Medicine 2015, 6: a023002. PMID: 26552702, PMCID: PMC4691806, DOI: 10.1101/cshperspect.a023002.Peer-Reviewed Original ResearchConceptsReproductive tract developmentEndometrial developmentTract developmentPolycystic ovarian syndromeFemale reproductive tract developmentFemale reproductive trackOvarian syndromeEndometrial receptivityImplantation rateFemale infertilityGene expressionMüllerian defectsHOXA11 expressionGene mutationsReproductive trackAdult functionDevelopmental abnormalitiesHOXA10AbnormalitiesEndocrine disruptorsDiethylstilbestrolImplantationEssential regulatorExpression
2012
Global Gene Expression Profiling of Proliferative Phase Endometrium Reveals Distinct Functional Subdivisions
Petracco RG, Kong A, Grechukhina O, Krikun G, Taylor HS. Global Gene Expression Profiling of Proliferative Phase Endometrium Reveals Distinct Functional Subdivisions. Reproductive Sciences 2012, 19: 1138-1145. PMID: 22623515, PMCID: PMC4052207, DOI: 10.1177/1933719112443877.Peer-Reviewed Original ResearchMeSH KeywordsAdultCell ProliferationChemokines, CCEmbryo ImplantationEndometriumFemaleFrizzled ReceptorsGene Expression ProfilingHeat-Shock ProteinsHedgehog ProteinsHumansKiller Cells, NaturalMenstrual CycleMetallothioneinReceptor, Angiotensin, Type 2Receptors, ProgesteroneTransforming Growth Factor beta2ConceptsLate proliferative phaseMid-proliferative phaseEarly proliferative phaseProliferative phaseNatural killer cell functionHigh expressionTime pointsKiller cell functionHigher serum levelsChemokine ligand 18Angiotensin II receptorsModulation of inflammationProliferative phase endometriumReal-time polymerase chain reactionQuantitative real-time polymerase chain reactionEstrogen-responsive growthGrowth factor β2Metallothionein 2A.Distinct functional subdivisionsUnique gene expression signatureGene expression signaturesEndometrial growthNK cellsSerum levelsEndometrial development
2009
Inflammation in Reproductive Disorders
Weiss G, Goldsmith LT, Taylor RN, Bellet D, Taylor HS. Inflammation in Reproductive Disorders. Reproductive Sciences 2009, 16: 216-229. PMID: 19208790, PMCID: PMC3107847, DOI: 10.1177/1933719108330087.Peer-Reviewed Original ResearchConceptsInflammatory disordersImmune responseReproductive-age womenNonspecific immune responsesImmune cell traffickingAnatomic disordersEndometrial developmentEndometrial functionEndometrial receptivityGynecologic diseaseInflammatory cytokinesAge womenImmune cellsMenstrual cycleInflammationTargeted treatmentReproductive disordersHormone productionCell traffickingInfectious diseasesNormal tissuesReproductive medicineDisordersTissue repairDisease
2008
Defining the proliferative phase endometrial defect
Bromer JG, Aldad TS, Taylor HS. Defining the proliferative phase endometrial defect. Fertility And Sterility 2008, 91: 698-704. PMID: 18314107, PMCID: PMC2699408, DOI: 10.1016/j.fertnstert.2007.12.066.Peer-Reviewed Original ResearchMeSH KeywordsAbortion, HabitualAdultClomipheneEndometriosisEndometriumFemaleFertility Agents, FemaleFertilization in VitroFollicle Stimulating HormoneFollicular PhaseHumansInfertility, FemaleInsemination, ArtificialMiddle AgedOvulation InductionPolycystic Ovary SyndromePregnancyPregnancy RateRetrospective StudiesRisk FactorsTime FactorsTreatment OutcomeUltrasonographyYoung AdultConceptsEndometrial thicknessCycle day 9Endometrial developmentDay 9Hormone-stimulated cyclesMaximum endometrial thicknessPeak endometrial thicknessClinical pregnancy ratePolycystic ovary syndromeRecurrent pregnancy lossBody mass indexClomiphene citrate cyclesCycle day 4Endometrial defectClomiphene citrateOvarian stimulationInfertility populationOvary syndromeEndometrial growthTransvaginal ultrasonographyMass indexInfertility practiceRetrospective studyControl subjectsPregnancy loss
2006
HOXA10 expression in ectopic endometrial tissue
Browne H, Taylor H. HOXA10 expression in ectopic endometrial tissue. Fertility And Sterility 2006, 85: 1386-1390. PMID: 16647375, DOI: 10.1016/j.fertnstert.2005.10.072.Peer-Reviewed Original ResearchConceptsEctopic endometrial tissueEndometrial tissueHOXA10 expressionEndometrial developmentEctopic endometriumEutopic endometriumLung parenchymaH-scoreNormal endometrial developmentEutopic endometrial tissuesPathogenesis of endometriosisHOXA10 protein expressionMean H-scoreOvarian endometriomaFertile womenPelvic peritoneumStromal expressionMAIN OUTCOMEEndometriosisGlandular epitheliumEndometriumDiminished expressionProtein expressionHOXA10P resistance
2003
HOXC and HOXD Gene Expression in Human Endometrium: Lack of Redundancy with HOXA Paralogs1
Akbas GE, Taylor HS. HOXC and HOXD Gene Expression in Human Endometrium: Lack of Redundancy with HOXA Paralogs1. Biology Of Reproduction 2003, 70: 39-45. PMID: 12954737, DOI: 10.1095/biolreprod.102.014969.Peer-Reviewed Original ResearchConceptsEndometrial developmentExpression of HOXC10Secretory phasePrimary endometrial stromal cellsSemiquantitative reverse transcription-polymerase chain reactionEndometrial stromal cellsReverse transcription-polymerase chain reactionTranscription-polymerase chain reactionEndometrial proliferationEndometrial receptivityEndometrial differentiationMenstrual cycleHuman endometriumIshikawa cellsSex steroidsDecreased expressionStromal cellsChain reactionEndometriumHOXA genesHOXA10HOXD10Distinct expression patternsSitu hybridizationHOXC10
2001
Maternal Hoxa10 is required for pinopod formation in the development of mouse uterine receptivity to embryo implantation
Bagot C, Kliman H, Taylor H. Maternal Hoxa10 is required for pinopod formation in the development of mouse uterine receptivity to embryo implantation. Developmental Dynamics 2001, 222: 538-544. PMID: 11747087, DOI: 10.1002/dvdy.1209.Peer-Reviewed Original ResearchConceptsEndometrial receptivityPinopod formationBlastocyst implantationHOXA10 expressionEndometrial stromal cell proliferationUterine endometrial epithelial cellsAdult female miceState of receptivityExpression of HOXA10Endometrial epithelial cellsStromal cell proliferationTime of implantationHOXA10 antisenseAdult reproductive tractEndometrial developmentGenitourinary tractFemale miceUterine receptivityMouse uterusUterusReproductive tractEpithelial cellsCell proliferationCellular proliferationHOXA10HOXA10 Expression Is Repressed by Progesterone in the Myometrium: Differential Tissue-Specific Regulation of HOX Gene Expression in the Reproductive Tract1
Cermik D, Karaca M, Taylor H. HOXA10 Expression Is Repressed by Progesterone in the Myometrium: Differential Tissue-Specific Regulation of HOX Gene Expression in the Reproductive Tract1. The Journal Of Clinical Endocrinology & Metabolism 2001, 86: 3387-3392. PMID: 11443215, DOI: 10.1210/jcem.86.7.7675.Peer-Reviewed Original ResearchConceptsHox gene expressionHOXA10 expressionHox genesDifferential tissue-specific regulationHigh serum progesterone levelsGene expressionPrimary myometrial cell culturesSerum progesterone levelsDevelopmental regulatory genesAdult human endometriumDifferential HOX gene expressionSteroid receptor coactivatorTissue-specific regulationTissue-specific responsesMyometrial cell culturesEndometrial developmentProgesterone receptorMenstrual cycleHuman endometriumMulticellular organismsNonpregnant uterusProgesterone levelsSex steroidsMidsecretory phaseMyometrium
2000
The Role of HOX Genes in the Development and Function of the Female Reproductive Tract
Taylor H. The Role of HOX Genes in the Development and Function of the Female Reproductive Tract. Seminars In Reproductive Medicine 2000, 18: 081-090. PMID: 11299523, DOI: 10.1055/s-2000-13478.Peer-Reviewed Original ResearchConceptsHox genesCommon genetic systemHox gene mutationsAdult functionReproductive tractEmbryonic patterningRegulatory genesGenetic systemTranscription factorsEmbryonic developmentFemale reproductive tractGenesReproductive tract developmentTract developmentGene mutationsMetazoansHuman endometrial developmentSpeciesRoleMutationsRegulationPatterningFunctionEndometrial developmentMüllerian system
1999
Sex Steroids Mediate HOXA11 Expression in the Human Peri-Implantation Endometrium1
Taylor H, Igarashi P, Olive D, Arici A. Sex Steroids Mediate HOXA11 Expression in the Human Peri-Implantation Endometrium1. The Journal Of Clinical Endocrinology & Metabolism 1999, 84: 1129-1135. PMID: 10084606, DOI: 10.1210/jcem.84.3.5573.Peer-Reviewed Original ResearchConceptsHuman endometriumEndometrial developmentSex steroidsHuman endometrial developmentPeri-implantation endometriumMaintenance of pregnancyDose-responsive increaseAdult human endometriumTime of implantationMessenger RNA levelsProgesterone concentrationsEndometriumHOXA11 expressionPhysiologic rangeRNA levelsSteroidsPotential rolePregnancyImplantationEstrogenHOXA11ExpressionGene expressionSequential developmentNorthern analysis
1998
HOXA10 is expressed in response to sex steroids at the time of implantation in the human endometrium.
Taylor H, Arici A, Olive D, Igarashi P. HOXA10 is expressed in response to sex steroids at the time of implantation in the human endometrium. Journal Of Clinical Investigation 1998, 101: 1379-1384. DOI: 10.1172/jci1057.Peer-Reviewed Original ResearchExpression of HOXA10Menstrual cycleTime of implantationSex steroidsCultured endometrial cellsUterine factor infertilityEffects of estrogenFactor infertilityEndometrial developmentEndometrial cellsHuman endometriumMidsecretory phaseHuman uterusPhysiologic rangeProgesteroneHOXA10Targeted disruptionNorthern blot analysisBlot analysisEstrogenSteroidsImplantationSitu hybridizationNovel regulatorExpression
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