2024
Endometrial stromal cell signaling and microRNA exosome content in women with adenomyosis
Zipponi M, Cacciottola L, Camboni A, Stratopoulou C, Taylor H, Dolmans M. Endometrial stromal cell signaling and microRNA exosome content in women with adenomyosis. Molecular Human Reproduction 2024, 31: gaae044. PMID: 39673794, DOI: 10.1093/molehr/gaae044.Peer-Reviewed Original ResearchStromal cell signalsMenstrual phaseHealthy subjectsPresence of endometrial glandsPathogenesis of adenomyosisCompared to controlsEndometrial biopsyEndometrial glandsEutopic endometriumStromal compartmentAdenomyosisAdenomyosis developmentMolecular mechanismsCell signalingLesion establishmentStromal cellsNanoparticle tracking analysisFlow cytometryEpithelial glandsParacrine signalingQuality of lifeSecreted exosomesIntercellular communicationExosomal contentsReproductive health
2018
Insulin Regulates Glycogen Synthesis in Human Endometrial Glands Through Increased GYS2
Flannery CA, Choe GH, Cooke KM, Fleming AG, Radford CC, Kodaman PH, Jurczak MJ, Kibbey RG, Taylor HS. Insulin Regulates Glycogen Synthesis in Human Endometrial Glands Through Increased GYS2. The Journal Of Clinical Endocrinology & Metabolism 2018, 103: 2843-2850. PMID: 29726999, PMCID: PMC6276707, DOI: 10.1210/jc.2017-01759.Peer-Reviewed Original ResearchConceptsGlucose metabolismGlycogen synthesisSecretory phase endometriumEndometrial epithelial cellsHuman endometrial glandsGlycogen synthase kinase 3α/βSynthase kinase 3α/βMaternal obesityHealthy womenEndometrial glandsEarly pregnancyHuman endometriumGSK3α/βOutcome measurementsSuccessful implantationFetal developmentEndometriumCritical metabolic functionsInsulinGlycogen contentProgesteroneSustain embryo developmentEpithelial cellsInsulin receptorPotential role
2017
The Systemic Effects of Endometriosis
Alderman MH, Yoder N, Taylor HS. The Systemic Effects of Endometriosis. Seminars In Reproductive Medicine 2017, 35: 263-270. PMID: 28658710, DOI: 10.1055/s-0037-1603582.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsSystemic effectsTreatment of patientsMultiple organ systemsMore effective treatmentsPelvic painEndometrial glandsAutoimmune diseasesBroader systemic effectsCardiovascular diseaseEffective treatmentEndometriosisBody weightPsychiatric conditionsOrgan systemsEctopic locationsStem cell migrationDiseaseComorbiditiesCell migrationTreatmentHypothesized mechanismsDysmenorrheaPainPatientsPathophysiology
2011
Novel Therapies Targeting Endometriosis
Taylor HS, Osteen KG, Bruner-Tran KL, Lockwood CJ, Krikun G, Sokalska A, Duleba AJ. Novel Therapies Targeting Endometriosis. Reproductive Sciences 2011, 18: 814-823. PMID: 21693775, PMCID: PMC4046304, DOI: 10.1177/1933719111410713.Peer-Reviewed Original ResearchConceptsNonhuman primate trialsAnti-inflammatory drugsProgesterone modulatorsEndometrial glandsPainful disordersNovel therapiesCommon causeSelective estrogenAntiangiogenic agentsWomen's qualityPotential therapyRodent modelsEndometriosisTherapyDiseaseStem cellsFurther testingPromising new developmentStatinsEstrogenInfertilityUterusStromaTrials
2010
Regulation of tryptophan 2,3-dioxygenase by HOXA10 enhances embryo viability through serotonin signaling
Doherty LF, Kwon HE, Taylor HS. Regulation of tryptophan 2,3-dioxygenase by HOXA10 enhances embryo viability through serotonin signaling. AJP Endocrinology And Metabolism 2010, 300: e86-e93. PMID: 20959529, PMCID: PMC3023205, DOI: 10.1152/ajpendo.00439.2010.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell LineDNA, AntisenseEmbryo ImplantationEmbryo, MammalianEmbryonic DevelopmentEndometriumFemaleHomeobox A10 ProteinsHomeodomain ProteinsHumansImmune ToleranceMiceOrgan SpecificityRandom AllocationReceptor, Serotonin, 5-HT1DReceptors, SerotoninRNA, MessengerSerotonin 5-HT1 Receptor AntagonistsSerotonin AntagonistsSignal TransductionT-LymphocytesTryptophan OxygenaseUterusConceptsTDO expressionSerotonin productionEndometrial stromaTDO mRNASerotonin receptor subtypesHOXA10 antisenseImmune toleranceImpaired embryo developmentEndometrial glandsSerotonin levelsMurine uterusReceptor subtypesT cellsSerotonin receptorsTryptophan catabolismEmbryo developmentEmbryo implantationTryptophan metabolismBiosynthesis of serotoninTryptophan availabilityHOXA10 expressionEmbryo qualitySerotoninHOXA10Regulation of tryptophan
2008
GnRH antagonists may affect endometrial receptivity
Rackow BW, Kliman HJ, Taylor HS. GnRH antagonists may affect endometrial receptivity. Fertility And Sterility 2008, 89: 1234-1239. PMID: 18410932, PMCID: PMC2699407, DOI: 10.1016/j.fertnstert.2007.04.060.Peer-Reviewed Original ResearchConceptsGnRH antagonistEndometrial stromal cellsEndometrial receptivityHOXA10 protein expressionHOXA10 expressionGnRH agonistControl subjectsProspective case-control studyStromal cellsEndometrial HOXA10 expressionPipelle endometrial biopsyProtein expressionSpontaneous LH surgeCase-control studyAcademic medical centerNatural cycleOvarian hyperstimulationRecombinant FSHEndometrial biopsyHCG administrationUntreated cyclesEndometrial glandsLH surgeMedical CenterMAIN OUTCOME
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