2025
Effect of endometriosis-linked microRNAs on hepatic gene expression
Mamillapalli R, Slutzky R, Mangla A, Gawde N, Taylor H. Effect of endometriosis-linked microRNAs on hepatic gene expression. F&S Science 2025, 6: 221-231. PMID: 39971156, DOI: 10.1016/j.xfss.2025.02.001.Peer-Reviewed Original ResearchMiR-3613-5pMiR-let-7bMiR-125b-5pMiR-150MiR-150-5pCirculating microRNAsMicroRNAsReactionExpression of IGFBP1Quantitative polymerase chain reactionSuppress target genesExpression of MRC1Polymerase chain reactionBinding sitesReal-time quantitative polymerase chain reactionHepatic gene expressionExpression of CYP2R1Bioinformatics analysisEffect of endometriosisSerum of womenCirculation of womenGene expressionChain reactionMiRsHepatic cells
2022
Endometriosis promotes atherosclerosis in a murine model
Mamillapalli R, Toffoloni N, Habata S, Qunhua H, Atwani R, Stachenfeld N, Taylor HS. Endometriosis promotes atherosclerosis in a murine model. American Journal Of Obstetrics And Gynecology 2022, 227: 248.e1-248.e8. PMID: 35351413, PMCID: PMC9308711, DOI: 10.1016/j.ajog.2022.03.040.Peer-Reviewed Original ResearchConceptsEffect of endometriosisOil Red O stainingVascular endothelial growth factorMurine modelCardiovascular diseaseRed O stainingEndothelial growth factorSham miceEndometriotic lesionsInflammatory cytokinesInterleukin-6Luminal areaInterferon gammaO stainingGrowth factorAortic luminal areasInflammatory-related cytokinesRoot wall thicknessUnderwent sham surgeryTreatment of endometriosisInflammation-related cytokinesDevelopment of atherosclerosisApolipoprotein E (ApoE-/- ) miceLong-term riskWeeks of induction
2019
Dose-Dependent Decreased Fertility in Response to the Burden of Endometriosis in a Murine Model
Rosa-e-Silva ACJS, Rosa-e-Silva JC, Mamillapalli R, Taylor HS. Dose-Dependent Decreased Fertility in Response to the Burden of Endometriosis in a Murine Model. Reproductive Sciences 2019, 26: 1395-1400. PMID: 31274059, PMCID: PMC6949971, DOI: 10.1177/1933719119859438.Peer-Reviewed Original ResearchConceptsMurine modelCurrent clinical staging systemBurden of endometriosisClinical staging systemClear dose-response relationshipDegree of painStage of diseaseEffect of endometriosisMechanism of infertilityGroups of miceSequelae of diseaseSeverity of symptomsDose-response relationshipSham surgery controlsActive diseaseDisease activityPelvic painStaging systemEarly recognitionEctopic tissueEndometrial cellsGynecological diseasesSurgery controlsPregnancy rateUterine tissueAdipocyte alterations in endometriosis: reduced numbers of stem cells and microRNA induced alterations in adipocyte metabolic gene expression
Zolbin MM, Mamillapalli R, Nematian SE, Goetz T, Taylor HS. Adipocyte alterations in endometriosis: reduced numbers of stem cells and microRNA induced alterations in adipocyte metabolic gene expression. Reproductive Biology And Endocrinology 2019, 17: 36. PMID: 30982470, PMCID: PMC6463663, DOI: 10.1186/s12958-019-0480-0.Peer-Reviewed Original ResearchConceptsBody mass indexFat metabolismFat tissueMouse modelAdipose tissueMetabolic gene expressionLower body mass indexOld female C57BL/6 miceAdipocytes of womenMicroRNA let‑7bSerum of womenReproductive-aged womenEffect of endometriosisFemale C57BL/6 miceStem cellsAdipose-derived mesenchymal stem cellsBrown adipocyte differentiationInhibitors of microRNAsStem cell contentMass indexMetabolic abnormalitiesC57BL/6 miceInflammatory disordersIL-6Insulin sensitivity
2018
Endometriosis alters brain electrophysiology, gene expression and increases pain sensitization, anxiety, and depression in female mice†
Li T, Mamillapalli R, Ding S, Chang H, Liu ZW, Gao XB, Taylor HS. Endometriosis alters brain electrophysiology, gene expression and increases pain sensitization, anxiety, and depression in female mice†. Biology Of Reproduction 2018, 99: 349-359. PMID: 29425272, PMCID: PMC6692844, DOI: 10.1093/biolre/ioy035.Peer-Reviewed Original ResearchConceptsEffect of endometriosisPain sensitizationPain perceptionBrain electrophysiologyEstrogen-dependent inflammatory disorderReproductive-aged womenDetection of endometriosisRegions of brainPatch-clamp recordingsCentral sensitizationPelvic painGene expressionInflammatory disordersEndometriosis miceFemale miceSham controlsMood disordersEndometriosisPainClamp recordingsBehavioral testsMiceBrain gene expressionSensitizationElectrophysiology
2016
Low Body Mass Index in Endometriosis Is Promoted by Hepatic Metabolic Gene Dysregulation in Mice1
Goetz L, Mamillapalli R, Taylor HS. Low Body Mass Index in Endometriosis Is Promoted by Hepatic Metabolic Gene Dysregulation in Mice1. Biology Of Reproduction 2016, 95: 115, 1-8. PMID: 27628219, PMCID: PMC5315422, DOI: 10.1095/biolreprod.116.142877.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBody Mass IndexBody WeightCholestanetriol 26-MonooxygenaseDisease Models, AnimalDown-RegulationEndometriosisEndometriumFatty Acid-Binding ProteinsFemaleGene Expression ProfilingInsulin-Like Growth Factor Binding Protein 1LiverMembrane GlycoproteinsMicePeritoneal DiseasesReceptors, Cell SurfaceReceptors, Immunologicrho-Associated KinasesUp-RegulationConceptsLower body mass indexBody mass indexMass indexBody fatBody weightDual-energy X-ray absorptiometry scanningLower total body fatEffect of endometriosisTotal body fatLower body weightLiver of miceExpression levelsHepatic gene expressionLiver gene expressionMultiorgan natureMouse endometriumEndometrial cellsFemale miceGene expressionPeritoneal cavityEndometriosisDisease endometriosisMiceWeight lossKey metabolic genesSexual function in endometriosis patients and their partners: effect of the disease and consequences of treatment
Pluchino N, Wenger JM, Petignat P, Tal R, Bolmont M, Taylor HS, Bianchi-Demicheli F. Sexual function in endometriosis patients and their partners: effect of the disease and consequences of treatment. Human Reproduction Update 2016, 22: 762-774. PMID: 27591248, DOI: 10.1093/humupd/dmw031.Peer-Reviewed Original ResearchConceptsSexual functionEndometriosis patientsPresence of dyspareuniaChronic pelvic painPresence of endometriosisEffect of surgeryOverall sexual functionEffect of endometriosisHalf of womenConsequence of treatmentQuality of lifeSystematic literature searchHealth care interventionsPelvic painDeep dyspareuniaSurgical treatmentMental comorbiditiesGynecologic disordersSexual painHormonal factorsHormonal treatmentMedical conditionsEndometriosisCoital painAdvanced stage
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