2025
Two-year follow-up study (PRIMROSE 3) to assess bone mineral density in subjects with uterine fibroids completing the PRIMROSE 1 and PRIMROSE 2 linzagolix trials
Donnez J, Petraglia F, Taylor H, Becker C, Becker S, Herrera F, Paszkowski M, Bestel E, Hori S, Dolmans M. Two-year follow-up study (PRIMROSE 3) to assess bone mineral density in subjects with uterine fibroids completing the PRIMROSE 1 and PRIMROSE 2 linzagolix trials. Human Reproduction Open 2025, 2025: hoaf025. PMID: 40575397, PMCID: PMC12202088, DOI: 10.1093/hropen/hoaf025.Peer-Reviewed Original ResearchDual-energy X-ray absorptiometryTotal hip bone mineral densityHip bone mineral densityBone mineral densityBaseline to monthAdd-back therapyLumbar spine bone mineral densitySpine bone mineral densityBone mineral density valuesAmerican Society of Reproductive MedicinePlacebo groupClinically relevant impactLumbar spineGedeon RichterOverall bone healthFemoral neckBaseline valuesTreatment groupsPrimary endpointSecondary endpointsL1-L4DEXA scanMineral densityFollow-up studyPre-treatment baseline values
2017
Cross-sex testosterone therapy in ovariectomized mice: addition of low-dose estrogen preserves bone architecture
Goetz TG, Mamillapalli R, Devlin MJ, Robbins AE, Majidi-Zolbin M, Taylor HS. Cross-sex testosterone therapy in ovariectomized mice: addition of low-dose estrogen preserves bone architecture. AJP Endocrinology And Metabolism 2017, 313: e540-e551. PMID: 28765273, PMCID: PMC5792142, DOI: 10.1152/ajpendo.00161.2017.Peer-Reviewed Original ResearchConceptsDual-energy X-ray absorptiometryBone mineral densityCross-sex hormone therapySpine bone mineral densityHormone therapyBone volume fractionBone acquisitionEstrogen treatmentTrabecular numberTrabecular separationComparable bone mineral densityLow-dose estrogen treatmentCortical area fractionPotential future clinical implicationsBone architectureEffects of testosteroneX-ray absorptiometryFuture clinical implicationsTestosterone therapyBone healthEstrogen lossOvariectomized miceTestosterone groupEstrogen deficiencyVehicle injection
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply