2025
TET3 is a common epigenetic immunomodulator of pathogenic macrophages
Liu B, Dai Y, Wang Z, Song J, Du Y, Lv H, Bellone S, Yang Y, Kennedy A, Zhang S, Venkatachalapathy M, Surovtseva Y, Wang P, Carmichael G, Taylor H, Zhang X, Li D, Huang Y. TET3 is a common epigenetic immunomodulator of pathogenic macrophages. Journal Of Clinical Investigation 2025 PMID: 40794443, DOI: 10.1172/jci194879.Peer-Reviewed Original ResearchThis study investigates the role of TET3 in promoting pathogenic macrophages across chronic inflammatory diseases, and shows that selectively eliminating TET3-overexpressing macrophages (“Toe-Macs”) can mitigate disease progression in conditions like MASH, NSCLC, and endometriosis.
2024
TET3-overexpressing macrophages promote endometriosis
Lv H, Liu B, Dai Y, Li F, Bellone S, Zhou Y, Mamillapalli R, Zhao D, Venkatachalapathy M, Hu Y, Carmichael G, Li D, Taylor H, Huang Y. TET3-overexpressing macrophages promote endometriosis. Journal Of Clinical Investigation 2024, 134: e181839. PMID: 39141428, PMCID: PMC11527447, DOI: 10.1172/jci181839.Peer-Reviewed Original ResearchDisease-associated macrophagesTET3 overexpressionHuman endometriosis lesionsPathophysiology of endometriosisPro-inflammatory cytokine productionChronic inflammatory diseaseReproductive age womenEndometriosis lesionsE3 ubiquitin ligasePathogenic macrophagesCytokine productionEndometriosisInflammatory diseasesTET3 knockdownEndometriosis progressionPathogenic contributorsLet-7 miRNA expressionAge womenMacrophagesMouse macrophagesTherapeutic targetUbiquitin ligaseTET3MiceDisease
2023
Unexplained Female Infertility Associated with Genetic Disease Variants
Dougherty M, Poch A, Chorich L, Hawkins Z, Xu H, Roman R, Liu H, Brakta S, Taylor H, Knight J, Kim H, Diamond M, Layman L. Unexplained Female Infertility Associated with Genetic Disease Variants. New England Journal Of Medicine 2023, 388: 1055-1056. PMID: 36920765, PMCID: PMC10134047, DOI: 10.1056/nejmc2211539.Peer-Reviewed Original Research
2021
Eliminating Hormones With Orally Active Gonadotropin-releasing Hormone Antagonists
Kotlyar AM, Pal L, Taylor HS. Eliminating Hormones With Orally Active Gonadotropin-releasing Hormone Antagonists. Clinical Obstetrics & Gynecology 2021, 64: 837-849. PMID: 34668887, DOI: 10.1097/grf.0000000000000664.Peer-Reviewed Original ResearchConceptsGnRH antagonistSmall molecule GnRH antagonistsClinical practiceSex steroid suppressionHormone-dependent diseasesSmall molecule antagonistsGnRH agonistSteroid suppressionGnRH analoguesGonadotropin productionHormone antagonistAntagonistHormone analogueGonadotropinActive gonadotropinsReproductive technologiesAgonistsDiseaseHormoneReimagining Endometriosis
Taylor HS. Reimagining Endometriosis. Med 2021, 2: 481-485. PMID: 35590229, DOI: 10.1016/j.medj.2021.04.026.Peer-Reviewed Original Research
2020
Elagolix in the treatment of endometriosis: impact beyond pain symptoms
Archer DF, Soliman AM, Agarwal SK, Taylor HS. Elagolix in the treatment of endometriosis: impact beyond pain symptoms. Therapeutic Advances In Reproductive Health 2020, 14: 2633494120964517. PMID: 33294846, PMCID: PMC7708701, DOI: 10.1177/2633494120964517.Peer-Reviewed Original ResearchPain symptomsSystemic manifestationsOral gonadotropin-releasing hormone receptor antagonistGonadotropin-releasing hormone receptor antagonistTreatment of endometriosisHormone receptor antagonistQuality of lifePelvic painSevere painCommon symptomsReceptor antagonistEndometriosisElagolixBeneficial effectsSymptomsPainManifestationsOutcomesPatientsWorkplace effectsAntagonistDiseaseWomen
2019
miR-45la Inhibition Reduces Established Endometriosis Lesions in Mice
Li M, Zhou Y, Taylor HS. miR-45la Inhibition Reduces Established Endometriosis Lesions in Mice. Reproductive Sciences 2019, 26: 1506-1511. PMID: 31354069, DOI: 10.1177/1933719119862050.Peer-Reviewed Original ResearchConceptsMiR-451a inhibitorReproductive-age womenTreatment of endometriosisPro-inflammatory diseasesSystemic treatmentEndometriosis lesionsIL-6Chronic diseasesPromising therapyCurrent treatmentMicroRNA-451aMurine modelSex steroidsEndometriosisLesion sizeVisible lesionsMiR-451aMicroRNAs treatmentsDiseaseAltered expressionΒ-cateninTreatmentLesionsInhibitorsMultiple pathwaysEndometriosis
Flores V, Taylor H. Endometriosis. DeckerMed Family Medicine 2019 DOI: 10.2310/fm.1005.Peer-Reviewed Original ResearchPelvic painSurgical therapyGrowth of endometriosisReproductive-age womenRole of estrogenDiagnosis of endometriosisGynecologic diseaseRetrograde menstruationCommon symptomsEndometriosis managementTreatment optionsPatient preferencesAge womenEndometriosisMolecular pathwaysPainPatientsAberrant gene expressionInfertilityTherapyDiseaseGene expressionDyspareuniaEstrogenEtiologyEndometriosis
Flores V, Taylor H. Endometriosis. DeckerMed Medicine 2019 DOI: 10.2310/im.1005.Peer-Reviewed Original ResearchPelvic painSurgical therapyGrowth of endometriosisReproductive-age womenRole of estrogenDiagnosis of endometriosisGynecologic diseaseRetrograde menstruationCommon symptomsEndometriosis managementTreatment optionsPatient preferencesAge womenEndometriosisMolecular pathwaysPainPatientsAberrant gene expressionInfertilityTherapyDiseaseGene expressionDyspareuniaEstrogenEtiologyUse of immunomodulators to treat endometriosis
Kotlyar A, Taylor H, D'Hooghe T. Use of immunomodulators to treat endometriosis. Best Practice & Research Clinical Obstetrics & Gynaecology 2019, 60: 56-65. PMID: 31515196, DOI: 10.1016/j.bpobgyn.2019.06.006.Peer-Reviewed Original ResearchConceptsDisease-modifying antirheumatic drugsEndometriosis-associated painPro-inflammatory stateTreatment of endometriosisUse of immunomodulatorsImmune cell populationsLimited human trialsImmunomodulating therapiesAntirheumatic drugsSymptom controlImmune dysfunctionChronic diseasesHuman trialsMTOR inhibitorsAnimal modelsAnimal studiesHuman studiesEndometriosisAberrant cytokineElevated levelsCell populationsCytokinesDiseaseLittle benefitTreatmentMicroRNAs in endometriosis: biological function and emerging biomarker candidates†
Bjorkman S, Taylor HS. MicroRNAs in endometriosis: biological function and emerging biomarker candidates†. Biology Of Reproduction 2019, 101: 1167-1178. PMID: 30721951, PMCID: PMC6497525, DOI: 10.1093/biolre/ioz014.Peer-Reviewed Original ResearchConceptsChronic diseasesReproductive-aged womenCommon chronic diseasesPathophysiology of endometriosisDisease-specific pathophysiologyRole of tissuePelvic painEndometriosis treatmentEndometriosisCandidate biomarkersPotential biomarkersNoninvasive toolSmall noncoding RNA moleculesDiseaseBiomarkersMultiple studiesPrecision medicineKey post-transcriptional regulatorsPathophysiologyNoncoding RNA moleculesMiRNA biomarkersDiagnosisMiRNA expressionFunctional pathwaysSpecific miRNAs
2017
The Systemic Effects of Endometriosis
Alderman MH, Yoder N, Taylor HS. The Systemic Effects of Endometriosis. Seminars In Reproductive Medicine 2017, 35: 263-270. PMID: 28658710, DOI: 10.1055/s-0037-1603582.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsSystemic effectsTreatment of patientsMultiple organ systemsMore effective treatmentsPelvic painEndometrial glandsAutoimmune diseasesBroader systemic effectsCardiovascular diseaseEffective treatmentEndometriosisBody weightPsychiatric conditionsOrgan systemsEctopic locationsStem cell migrationDiseaseComorbiditiesCell migrationTreatmentHypothesized mechanismsDysmenorrheaPainPatientsPathophysiologyMicrometastasis of endometriosis to distant organs in a murine model
Samani EN, Mamillapalli R, Li F, Mutlu L, Hufnagel D, Krikun G, Taylor HS. Micrometastasis of endometriosis to distant organs in a murine model. Oncotarget 2017, 10: 2282-2291. PMID: 31040919, PMCID: PMC6481344, DOI: 10.18632/oncotarget.16889.Peer-Reviewed Original ResearchPeritoneal cavityMultiple organsDistant organsDiffuse clinical manifestationsMurine endometriosis modelReproductive-aged womenDisseminated endometriosisEndometriosis modelRetrograde menstruationClinical manifestationsEndometrial tissueEndometriotic lesionsImmunocompetent miceFallopian tubeEndometrial cellsGynecological disordersMurine modelMouse modelEndometriosisExperimental animalsEngraftmentMicrometastasisImmunofluorescence analysisOrgansDisease
2016
Endometriosis Located Proximal to or Remote From the Uterus Differentially Affects Uterine Gene Expression
Naqvi H, Mamillapalli R, Krikun G, Taylor HS. Endometriosis Located Proximal to or Remote From the Uterus Differentially Affects Uterine Gene Expression. Reproductive Sciences 2016, 23: 186-191. PMID: 26516123, PMCID: PMC5933175, DOI: 10.1177/1933719115613449.Peer-Reviewed Original ResearchConceptsUterine gene expressionEndometrial receptivityEutopic endometriumSystemic effectsExpression of HOXA10Peritoneal diseasePeritoneal endometriosisEndometriosis lesionsEndometriotic lesionsSystemic diseaseDistal lesionsRemote diseaseGene expressionMurine modelEnd organsEndometriosisPeritoneal cavityPGR geneDiseaseLesionsSelective alterationsMiceWidespread manifestationsEndometriumUterus
2014
Endometrial stem cell transplantation in MPTP‐ exposed primates: an alternative cell source for treatment of Parkinson's disease
Wolff EF, Mutlu L, Massasa EE, Elsworth JD, Redmond D, Taylor HS. Endometrial stem cell transplantation in MPTP‐ exposed primates: an alternative cell source for treatment of Parkinson's disease. Journal Of Cellular And Molecular Medicine 2014, 19: 249-256. PMID: 25283241, PMCID: PMC4288367, DOI: 10.1111/jcmm.12433.Peer-Reviewed Original ResearchConceptsEndometrium-derived stem cellsParkinson's diseaseTyrosine hydroxylaseStem cellsDopamine metabolite concentrationsStem cell transplantationTH-positive cellsNeuron-like morphologyTransplanted sideNeuronal lossCell transplantationDopaminergic neuronsSubstantia nigraPrimate modelCell replacement therapyMonkey modelTherapeutic benefitAlternative cell sourcePositive cellsCellular therapyNeurodegenerative diseasesDiseaseTherapyEase of collectionMetabolite concentrations
2013
Stem cells and the reproductive system: Historical perspective and future directions
Duke CM, Taylor HS. Stem cells and the reproductive system: Historical perspective and future directions. Maturitas 2013, 76: 284-289. PMID: 24144960, DOI: 10.1016/j.maturitas.2013.08.012.Peer-Reviewed Original ResearchConceptsEndometrial-derived stem cellsStem cellsNumber of oocytesBone marrow stem cellsFuture therapeutic benefitMarrow stem cellsEndometrial regenerationParenchymal regenerationEndometrial tissueFertility preservationUterine disordersDerived stem cellsFetal stem cellsHuman ovaryMaternal circulationParkinson's diseaseTherapeutic benefitNovel treatmentsMultipotent stem cellsFetal cellsReproductive diseasesDiseaseDisease statesMature oocytesReproductive system
2011
Novel Therapies Targeting Endometriosis
Taylor HS, Osteen KG, Bruner-Tran KL, Lockwood CJ, Krikun G, Sokalska A, Duleba AJ. Novel Therapies Targeting Endometriosis. Reproductive Sciences 2011, 18: 814-823. PMID: 21693775, PMCID: PMC4046304, DOI: 10.1177/1933719111410713.Peer-Reviewed Original ResearchConceptsNonhuman primate trialsAnti-inflammatory drugsProgesterone modulatorsEndometrial glandsPainful disordersNovel therapiesCommon causeSelective estrogenAntiangiogenic agentsWomen's qualityPotential therapyRodent modelsEndometriosisTherapyDiseaseStem cellsFurther testingPromising new developmentStatinsEstrogenInfertilityUterusStromaTrialsStem cells in endometrium and their role in the pathogenesis of endometriosis
Figueira PG, Abrão MS, Krikun G, Taylor H. Stem cells in endometrium and their role in the pathogenesis of endometriosis. Annals Of The New York Academy Of Sciences 2011, 1221: 10-17. PMID: 21401624, PMCID: PMC3076708, DOI: 10.1111/j.1749-6632.2011.05969.x.Peer-Reviewed Original ResearchConceptsProgenitor stem cellsPathogenesis of endometriosisMesenchymal stem cellsMultipotent stem cellsStem cellsAdult progenitor stem cellsEndometrial stem cellsDopaminergic neuronsMenstrual cycleHuman endometriumRetrograde fashionMurine modelPeritoneal cavityParkinson's diseaseEndometriosisBone marrowRemarkable regenerative capacityEndometriumEctopic locationsRegenerative capacityPathogenesisDiseaseNeuronsDynamic tissueCellsDiagnosis and Management of Infertility due to Endometriosis
Luk J, Taylor H. Diagnosis and Management of Infertility due to Endometriosis. 2011, 38-47. DOI: 10.1002/9781444393958.ch5.Peer-Reviewed Original Research
2010
Environmental induction of the fetal epigenome
Odom LN, Taylor HS. Environmental induction of the fetal epigenome. Expert Review Of Obstetrics & Gynecology 2010, 5: 657-664. PMID: 21297874, PMCID: PMC3032386, DOI: 10.1586/eog.10.58.Peer-Reviewed Original ResearchFetal epigenomeReproductive-age womenMaternal environmentUtero exposureBarker hypothesisHealthy adultsHealthcare providersAdult HealthVulnerable timeProfound epigenetic effectsEnvironmental exposuresFetusesEpigenetic alterationsEpigenomic alterationsExposureAlterationsNumerous studiesEpigenetic effectsFurther supportPregnancyDiseaseDNA methylation
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