2025
Observational and Genetic Analyses of Traumatic Experiences and Endometriosis
Koller D, Løkhammer S, Goroshchuk O, Denner V, Stiltner B, Mitjans M, He J, Taylor H, Lawn R, Koenen K, Polimanti R. Observational and Genetic Analyses of Traumatic Experiences and Endometriosis. JAMA Psychiatry 2025, 82: 386-394. PMID: 39908042, PMCID: PMC11800128, DOI: 10.1001/jamapsychiatry.2024.4694.Peer-Reviewed Original ResearchPolygenic risk scoresLatent class analysisAssociated with increased oddsTraumatic experiencesImpact of childhoodIndividual-level dataCase-control studyStressful eventsGenetic predispositionTrauma-related outcomesUnaffected womenMain OutcomesFinnGen cohortRisk scoreAssociation of endometriosisPosttraumatic stress disorderTrauma eventsMeta-analysisSexual traumaAssociated with endometriosisContact traumaPotential associationStress disorderPsychological traumaPhenotypic associations
2019
Lack of an Association between a Polymorphism in the KRAS 3′ Untranslated Region (rs61764370) and Endometriosis in a Large European Case-Control Study
D'Hooghe TM, Grechukhina O, Cho S, Fassbender A, O D, Peterse D, Weidhaas J, Taylor HS. Lack of an Association between a Polymorphism in the KRAS 3′ Untranslated Region (rs61764370) and Endometriosis in a Large European Case-Control Study. Gynecologic And Obstetric Investigation 2019, 84: 575-582. PMID: 31185482, DOI: 10.1159/000500626.Peer-Reviewed Original ResearchConceptsCase-control studyGerm-line single nucleotide polymorphismsKRAS geneLarge case-control studyReproductive-age womenType of infertilityBody mass indexEuropean case-control studyKRAS 3' untranslated regionLarge European case-control studyMicroRNA-binding sitesMedical therapyPeritoneal biopsiesMass indexPeripheral bloodAge womenPolymerase chain reactionCommon disorderTreatment resistanceEndometriosisCarrier rateVariant allelesCaucasian populationGene variantsKRAS allele
2017
Systemic Inflammation Induced by microRNAs: Endometriosis-Derived Alterations in Circulating microRNA 125b-5p and Let-7b-5p Regulate Macrophage Cytokine Production
Nematian SE, Mamillapalli R, Kadakia TS, Zolbin M, Moustafa S, Taylor HS. Systemic Inflammation Induced by microRNAs: Endometriosis-Derived Alterations in Circulating microRNA 125b-5p and Let-7b-5p Regulate Macrophage Cytokine Production. The Journal Of Clinical Endocrinology & Metabolism 2017, 103: 64-74. PMID: 29040578, DOI: 10.1210/jc.2017-01199.Peer-Reviewed Original ResearchConceptsSera of patientsMacrophage cytokine productionIL-1βIL-6Cytokine productionIL-8Let-7bIL-1β levelsCytokine protein levelsU937 macrophage cell lineCase-control studyTumor necrosis factorLet-7b inhibitorReal-time polymerase chain reactionEnzyme-linked immunosorbentQuantitative real-time polymerase chain reactionMessenger RNA changesSystemic inflammationAberrant inflammationInflammatory cytokinesProinflammatory cytokinesLevels of microRNAsUniversity HospitalPolymerase chain reactionMacrophage cell line
2016
Serum microRNAs as diagnostic markers of endometriosis: a comprehensive array-based analysis
Cosar E, Mamillapalli R, Ersoy GS, Cho S, Seifer B, Taylor HS. Serum microRNAs as diagnostic markers of endometriosis: a comprehensive array-based analysis. Fertility And Sterility 2016, 106: 402-409. PMID: 27179784, DOI: 10.1016/j.fertnstert.2016.04.013.Peer-Reviewed Original ResearchMeSH KeywordsAdultArea Under CurveCase-Control StudiesConnecticutEndometriosisFemaleGene Expression ProfilingGenetic MarkersGenetic Predisposition to DiseaseHospitals, UniversityHumansLogistic ModelsMicroRNAsOligonucleotide Array Sequence AnalysisPhenotypePredictive Value of TestsReal-Time Polymerase Chain ReactionReproducibility of ResultsROC CurveSeoulConceptsMiR-451aMiR-125bSerum microRNAsCase-control studyMiR-150-5pSingle diagnostic biomarkerReal-time polymerase chain reactionQuantitative real-time polymerase chain reactionLogistic regression modelsMiR-342-3pMiR-145-5pPolymerase chain reactionUniversity HospitalDiagnosed subjectsMAIN OUTCOMEEndometriosisDiagnostic biomarkersMiR-500aDiagnostic markerSerum samplesDiagnostic performanceROC curveQRT-PCRChain reactionWomen
2015
Circulating microRNAs as potential biomarkers for endometriosis
Cho S, Mutlu L, Grechukhina O, Taylor HS. Circulating microRNAs as potential biomarkers for endometriosis. Fertility And Sterility 2015, 103: 1252-1260.e1. PMID: 25772772, PMCID: PMC4417410, DOI: 10.1016/j.fertnstert.2015.02.013.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultArea Under CurveCase-Control StudiesCell ProliferationEndometriosisFemaleGenetic MarkersHospitals, UniversityHumansLogistic ModelsMicroRNAsMiddle AgedPredictive Value of TestsReal-Time Polymerase Chain ReactionReverse Transcriptase Polymerase Chain ReactionROC CurveYoung AdultConceptsProliferative phaseLet-7bSerum CA-125 levelsMiR-135aCA-125 levelsSerum of womenBenign gynecologic diseaseCase-control studyQuantitative reverse transcription polymerase chain reactionReverse transcription-polymerase chain reactionPotential noninvasive biomarkersLogistic regression modelsHighest areaGynecologic diseasePolymerase chain reactionUniversity HospitalMenstrual cycleEndometriosisMAIN OUTCOMENoninvasive biomarkersPotential biomarkersDiagnostic markerSerum samplesWomenChain reaction
2011
Endometrial polyps affect uterine receptivity
Rackow BW, Jorgensen E, Taylor HS. Endometrial polyps affect uterine receptivity. Fertility And Sterility 2011, 95: 2690-2692. PMID: 21269620, PMCID: PMC3096716, DOI: 10.1016/j.fertnstert.2010.12.034.Peer-Reviewed Original Research
2009
A novel mutation of HOXA13 in a family with hand-foot-genital syndrome and the role of polyalanine expansions in the spectrum of Müllerian fusion anomalies
Jorgensen EM, Ruman JI, Doherty L, Taylor HS. A novel mutation of HOXA13 in a family with hand-foot-genital syndrome and the role of polyalanine expansions in the spectrum of Müllerian fusion anomalies. Fertility And Sterility 2009, 94: 1235-1238. PMID: 19591980, PMCID: PMC2889242, DOI: 10.1016/j.fertnstert.2009.05.057.Peer-Reviewed Original ResearchConceptsGenital syndromeMüllerian fusion anomaliesCase-control studyAcademic medical centerNovel mutationsFoot symptomsFusion anomaliesAbsence of mutationsMedical CenterMAIN OUTCOMENormal controlsBiopsy samplesPatientsDistal limbSeptumSyndromeHFGSFamily membersHOXA13MutationsPolyalanine tractPolyalanine expansionsSequelaeRoentgenogramsSymptoms
2008
Decreased endometrial HOXA10 expression associated with use of the copper intrauterine device
Tetrault AM, Richman SM, Fei X, Taylor HS. Decreased endometrial HOXA10 expression associated with use of the copper intrauterine device. Fertility And Sterility 2008, 92: 1820-1824. PMID: 18930214, PMCID: PMC2811037, DOI: 10.1016/j.fertnstert.2008.08.134.Peer-Reviewed Original ResearchConceptsEndometrial HOXA10 expressionCopper intrauterine deviceIntrauterine deviceHOXA10 expressionBiopsy samplesEndometrial receptivityEndometrial biopsy samplesNormal cycling womenCase-control studyExpression of HOXA10Academic medical centerMean H-scoreGlandular expressionIUD contraceptivesHormonal contraceptivesCycling womenContraceptive efficacyIUD useMedical CenterIUD usersMAIN OUTCOMEImmunohistochemical analysisH-scoreEndometrial HOXA10WomenSubmucosal uterine leiomyomas have a global effect on molecular determinants of endometrial receptivity
Rackow BW, Taylor HS. Submucosal uterine leiomyomas have a global effect on molecular determinants of endometrial receptivity. Fertility And Sterility 2008, 93: 2027-2034. PMID: 18555231, PMCID: PMC3107853, DOI: 10.1016/j.fertnstert.2008.03.029.Peer-Reviewed Original ResearchMeSH KeywordsAdultBiomarkers, TumorCase-Control StudiesEmbryo ImplantationEndometriumFemaleGene Expression Regulation, NeoplasticHomeobox A10 ProteinsHomeodomain ProteinsHumansInfertility, FemaleKruppel-Like Transcription FactorsLeiomyomaLeukemia Inhibitory FactorMiddle AgedMucous MembranePrognosisUterine NeoplasmsConceptsReal-time reverse transcriptase-polymerase chain reactionSubmucosal myomasEndometrial receptivityUterine leiomyomaMRNA expressionEndometrial HOXA10 expressionSubmucosal uterine leiomyomasLIF mRNA expressionReproductive-aged womenTime of surgeryCase-control studyReverse transcriptase-polymerase chain reactionHOXA10 protein expressionQuantitative real-time reverse transcriptase-polymerase chain reactionUniversity Medical CenterTranscriptase-polymerase chain reactionMessenger RNA expressionReal-time RT-PCREndometrial samplingPrimary endpointEndometrial biopsyUterine myomaIntramural myomasMedical CenterReproductive dysfunctionGnRH antagonists may affect endometrial receptivity
Rackow BW, Kliman HJ, Taylor HS. GnRH antagonists may affect endometrial receptivity. Fertility And Sterility 2008, 89: 1234-1239. PMID: 18410932, PMCID: PMC2699407, DOI: 10.1016/j.fertnstert.2007.04.060.Peer-Reviewed Original ResearchConceptsGnRH antagonistEndometrial stromal cellsEndometrial receptivityHOXA10 protein expressionHOXA10 expressionGnRH agonistControl subjectsProspective case-control studyStromal cellsEndometrial HOXA10 expressionPipelle endometrial biopsyProtein expressionSpontaneous LH surgeCase-control studyAcademic medical centerNatural cycleOvarian hyperstimulationRecombinant FSHEndometrial biopsyHCG administrationUntreated cyclesEndometrial glandsLH surgeMedical CenterMAIN OUTCOME
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