2025
Short-term estradiol administration does not restore endothelin‐B receptor‐mediated vasodilation in postmenopausal women
Nuckols V, Shoemaker L, Kuczmarski A, Haigh K, McGinty S, Del Vecchio A, Schwab A, Edwards D, Taylor H, Wenner M. Short-term estradiol administration does not restore endothelin‐B receptor‐mediated vasodilation in postmenopausal women. AJP Heart And Circulatory Physiology 2025, 328: h327-h332. PMID: 39773019, PMCID: PMC12175985, DOI: 10.1152/ajpheart.00815.2024.Peer-Reviewed Original ResearchConceptsPostmenopausal womenExogenous estradiol administrationEndothelin B receptorEstradiol administrationPremenopausal womenLactated RingeHealthy postmenopausal womenYoung womenLaser Doppler flowmetryEndothelin-BVasodilatory responseTransdermal patchDoppler flowmetryCutaneous microcirculationVasodilationEstradiolAdministrationWomenReceptorsRingerBlockadeFlowmetry
2017
Microvascular endothelial function in lean versus obese women with polycystic ovary syndrome: role of the endothelin B receptor
Usselman C, Taylor H, Stachenfeld N. Microvascular endothelial function in lean versus obese women with polycystic ovary syndrome: role of the endothelin B receptor. The FASEB Journal 2017, 31 DOI: 10.1096/fasebj.31.1_supplement.691.5.Peer-Reviewed Original ResearchPolycystic ovary syndromeLean polycystic ovary syndromeObese PCOS womenCutaneous vascular conductanceNitric oxide inhibitionObese womenET-1PCOS womenOvary syndromeVasodilatory responseEndothelial functionOxide inhibitionEndothelin receptor subtype BObese polycystic ovary syndromeIntradermal microdialysis perfusionCardiovascular risk factorsMicrovascular endothelial functionPlasma endothelin-1Adverse cardiovascular outcomesAmerican Heart AssociationEndothelin B receptorLaser Doppler flowmetryDose-response curveCardiovascular outcomesIndependent vasodilation
2015
Peripheral Microvascular Vasodilatory Response to Estradiol and Genistein in Women with Insulin Resistance
Wenner MM, Taylor HS, Stachenfeld NS. Peripheral Microvascular Vasodilatory Response to Estradiol and Genistein in Women with Insulin Resistance. Microcirculation 2015, 22: 391-399. PMID: 25996650, PMCID: PMC4506724, DOI: 10.1111/micc.12208.Peer-Reviewed Original ResearchConceptsL-NMMAMicrovascular vasodilationHealthy womenVasodilatory responsivenessLocal cutaneous heatingMicrovascular vasodilatory functionMicrovascular vasodilatory responsesBeat blood pressureHealthy young womenLaser Doppler flowmetryHeat-induced vasodilationMicrovascular responsivenessVascular effectsVasodilatory responseBlood pressureMicrovascular functionVasodilatory functionCutaneous heatingInsulin resistanceCutaneous circulationDoppler flowmetryGEN exposureInteraction of E2VasodilationMicrodialysis perfusion
2011
Endothelin B receptor contribution to peripheral microvascular function in women with polycystic ovary syndrome
Wenner MM, Taylor HS, Stachenfeld NS. Endothelin B receptor contribution to peripheral microvascular function in women with polycystic ovary syndrome. The Journal Of Physiology 2011, 589: 4671-4679. PMID: 21825025, PMCID: PMC3213415, DOI: 10.1113/jphysiol.2011.216218.Peer-Reviewed Original ResearchMeSH KeywordsAdultCardiovascular DiseasesEndothelin A Receptor AntagonistsEndothelin B Receptor AntagonistsEndothelin-1Endothelin-2Endothelium, VascularFemaleHumansMicrocirculationMicrovesselsOligopeptidesPeptides, CyclicPiperidinesPolycystic Ovary SyndromeReceptor, Endothelin AReceptor, Endothelin BRegional Blood FlowSkinVasoconstrictionVasodilationYoung AdultConceptsPolycystic ovary syndromeET-B receptorsLocal skin warmingOvary syndromeSkin warmingLower vascular reactivityPeripheral microvascular functionLaser Doppler flowmetrySkin blood flowGroup of womenDose-response curveBlunted responsivenessEndothelin BEndothelin AEndothelial dysfunctionVascular reactivityVasoconstrictive responseVasodilatory responseMicrovascular functionCutaneous microvasculatureIntradermal microdialysisAntagonist infusionEndothelin-1Receptor responsivenessReceptor subtypesSex differences in endothelial function in the microvasculature: effects of PCOS
Stachenfeld N, Wenner M, Taylor H. Sex differences in endothelial function in the microvasculature: effects of PCOS. The FASEB Journal 2011, 25: 837.2-837.2. DOI: 10.1096/fasebj.25.1_supplement.837.2.Peer-Reviewed Original ResearchPolycystic ovary syndromeETB receptorsEffects of PCOSHeart disease riskLaser Doppler flowmetrySkin blood flowNormal reproductive functionDose-response curveEndothelial dysfunctionOvary syndromeVasoconstrictive responseVasodilatory responseEndothelial functionCutaneous microvasculatureETA receptorsHealthy womenAntagonist infusionDoppler flowmetrySmooth muscleBlood flowReceptor AReproductive functionDisease riskWomenReceptors
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