2025
Impact of peritoneal macrophage depletion on endometriotic lesion development in a mouse model
Stratopoulou C, Cacciottola L, Gawde N, Ngombo A, Brusa D, Donnez J, Taylor H, Dolmans M. Impact of peritoneal macrophage depletion on endometriotic lesion development in a mouse model. Journal Of Endometriosis And Uterine Disorders 2025, 10: 100113. DOI: 10.1016/j.jeud.2025.100113.Peer-Reviewed Original ResearchMacrophage depletionEndometriotic lesionsTreated miceMacrophage accumulationMouse modelVascular endothelial growth factor immunostainingEndometriosis developmentQuantification of immune cellsFlow cytometryMouse model of endometriosisClodronate-containing liposomesKi67-positive proliferating cellsNovel therapeutic optionsRate of fibrosisModel of endometriosisTUNEL-positive apoptotic cellsLevels of fibrosisPathogenesis of endometriosisReproductive-age womenMasson's trichrome stainingEndometriotic lesion developmentEnhanced cell deathPlacebo-ControlledUterine fragmentsT cells
2016
Bisphenol A (BPA) Exposure In Utero Leads to Immunoregulatory Cytokine Dysregulation in the Mouse Mammary Gland: A Potential Mechanism Programming Breast Cancer Risk
Fischer C, Mamillapalli R, Goetz T, Jorgenson E, Ilagan Y, Taylor HS. Bisphenol A (BPA) Exposure In Utero Leads to Immunoregulatory Cytokine Dysregulation in the Mouse Mammary Gland: A Potential Mechanism Programming Breast Cancer Risk. Discover Oncology 2016, 7: 241-251. PMID: 26911702, PMCID: PMC10726733, DOI: 10.1007/s12672-016-0254-5.Peer-Reviewed Original ResearchConceptsBPA exposureBreast cancerAdaptive immunityMammary glandPosterior mammary glandsTh1 T cellsAberrant immune responseAbnormal mammary gland developmentHuman breast cancerPossible environmental etiologyInterleukin-1 gene familyMammary gland developmentMouse mammary tissueCytolytic CD8Osmotic minipumpsCD1 miceT cellsImmune responseGene familyExpression of membersCXC familyMammary tissueDevelopmental programmingUteroWestern blot
2010
Regulation of tryptophan 2,3-dioxygenase by HOXA10 enhances embryo viability through serotonin signaling
Doherty LF, Kwon HE, Taylor HS. Regulation of tryptophan 2,3-dioxygenase by HOXA10 enhances embryo viability through serotonin signaling. AJP Endocrinology And Metabolism 2010, 300: e86-e93. PMID: 20959529, PMCID: PMC3023205, DOI: 10.1152/ajpendo.00439.2010.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell LineDNA, AntisenseEmbryo ImplantationEmbryo, MammalianEmbryonic DevelopmentEndometriumFemaleHomeobox A10 ProteinsHomeodomain ProteinsHumansImmune ToleranceMiceOrgan SpecificityRandom AllocationReceptor, Serotonin, 5-HT1DReceptors, SerotoninRNA, MessengerSerotonin 5-HT1 Receptor AntagonistsSerotonin AntagonistsSignal TransductionT-LymphocytesTryptophan OxygenaseUterusConceptsTDO expressionSerotonin productionEndometrial stromaTDO mRNASerotonin receptor subtypesHOXA10 antisenseImmune toleranceImpaired embryo developmentEndometrial glandsSerotonin levelsMurine uterusReceptor subtypesT cellsSerotonin receptorsTryptophan catabolismEmbryo developmentEmbryo implantationTryptophan metabolismBiosynthesis of serotoninTryptophan availabilityHOXA10 expressionEmbryo qualitySerotoninHOXA10Regulation of tryptophan
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