2025
The role of long non-coding ribonucleic acid HOXA11-AS in endometriosis therapy
Mamillapalli R, Gawde N, Fay M, Atwani R, Moridi I, Taylor H. The role of long non-coding ribonucleic acid HOXA11-AS in endometriosis therapy. Reproductive Biology And Endocrinology 2025, 23: 83. PMID: 40457415, PMCID: PMC12128536, DOI: 10.1186/s12958-025-01420-0.Peer-Reviewed Original ResearchConceptsHOXA11-ASHOXA11-AS expressionEutopic endometriumLong non-coding RNAsEctopic endometriotic lesionsEndometriotic cell linesInvasion of endometriosisEndometrial stromal cellsReal-time polymerase chain reactionNon-coding RNAsEndometriotic lesionsEndometriosis therapyEndometriosis patientsNormal endometriumProgestin responsivenessEndometrial developmentTreatment responsePolymerase chain reactionQuantitative real-time polymerase chain reactionEndometriosisEndometriosis treatmentMethodsTissue samplesStromal cellsPotential target genesEndometrium
2024
Endometrial stromal cell signaling and microRNA exosome content in women with adenomyosis
Zipponi M, Cacciottola L, Camboni A, Stratopoulou C, Taylor H, Dolmans M. Endometrial stromal cell signaling and microRNA exosome content in women with adenomyosis. Molecular Human Reproduction 2024, 31: gaae044. PMID: 39673794, DOI: 10.1093/molehr/gaae044.Peer-Reviewed Original ResearchStromal cell signalsMenstrual phaseHealthy subjectsPresence of endometrial glandsPathogenesis of adenomyosisCompared to controlsEndometrial biopsyEndometrial glandsEutopic endometriumStromal compartmentAdenomyosisAdenomyosis developmentMolecular mechanismsCell signalingLesion establishmentStromal cellsNanoparticle tracking analysisFlow cytometryEpithelial glandsParacrine signalingQuality of lifeSecreted exosomesIntercellular communicationExosomal contentsReproductive health
2021
Endometriosis stromal cells induce bone marrow mesenchymal stem cell differentiation and PD-1 expression through paracrine signaling
Chen P, Mamillapalli R, Habata S, Taylor HS. Endometriosis stromal cells induce bone marrow mesenchymal stem cell differentiation and PD-1 expression through paracrine signaling. Molecular And Cellular Biochemistry 2021, 476: 1717-1727. PMID: 33428059, DOI: 10.1007/s11010-020-04012-1.Peer-Reviewed Original ResearchConceptsPD-1 expressionPD-1Stromal cellsT-cell PD-1 expressionEndometriosis stromal cellsGrowth of endometriosisPD-1 inductionDifferentiation of BMDCsBone marrow mesenchymal stem cell differentiationT cell quiescenceBMDC differentiationImmune toleranceEndometriosis patientsEndometriotic lesionsNormal endometriumEndometrial cellsEndometriosis cellsGynecological disordersImmune surveillanceMurine modelBMDCsEndometriosisLesion sizeCXCR4 receptorLesions
2019
Potential roles of aquaporin 9 in the pathogenesis of endometriosis
Choi YS, Park JH, Yoon JK, Yoon JS, Kim JS, Lee JH, Yun BH, Park JH, Seo SK, Cho S, Lee BS, Taylor HS. Potential roles of aquaporin 9 in the pathogenesis of endometriosis. Molecular Human Reproduction 2019, 25: 373-384. PMID: 31070762, DOI: 10.1093/molehr/gaz025.Peer-Reviewed Original ResearchConceptsHuman endometrial stromal cellsPathogenesis of endometriosisEndometrial stromal cellsPotential therapeutic targetExpression of MMP2P38 MAPK proteinWestern blot analysisControl patientsEndometrial expressionPhosphorylated ERK 1/2Ectopic endometriumEutopic endometriumInflammatory processLaparoscopic surgeryEndometriosisTherapeutic targetBenign conditionsAQP subtypesExpression of AQP9Stromal cellsTumor developmentWestern blottingAQP9 expressionHealing assaysERK 1/2
2016
Endometrial Cancer-Associated FGF18 Expression Is Reduced by Bazedoxifene in Human Endometrial Stromal Cells In Vitro and in Murine Endometrium
Flannery CA, Fleming AG, Choe GH, Naqvi H, Zhang M, Sharma A, Taylor HS. Endometrial Cancer-Associated FGF18 Expression Is Reduced by Bazedoxifene in Human Endometrial Stromal Cells In Vitro and in Murine Endometrium. Endocrinology 2016, 157: 3699-3708. PMID: 27267714, PMCID: PMC5045514, DOI: 10.1210/en.2016-1233.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overAnimalsBasic Helix-Loop-Helix Transcription FactorsCarcinoma, EndometrioidCase-Control StudiesCells, CulturedEndometrial HyperplasiaEndometrial NeoplasmsEndometriumFemaleFibroblast Growth FactorsGene Expression ProfilingHumansIndolesMiceMiddle AgedSelective Estrogen Receptor ModulatorsConceptsStromal cellsPostmenopausal womenHormone therapyEpithelial proliferationFGF18 expressionAntiproliferative effectsSelective estrogen receptor modulatorsHuman endometrial stromal cellsGrowth factorBZA/CEMenopausal hormone therapyEndometrial stromal cellsBreast cancer riskEstrogen receptor modulatorsCD1 female miceE74-like factor 5Normal proliferative endometriumParacrine growth factorPrimary stromal cellsTyrosine kinase receptor 2Fibroblast growth factorEndometrial hyperplasiaEndometrial proliferationEndometrial cancerEndometrial adenocarcinoma
2015
H19 lncRNA alters stromal cell growth via IGF signaling in the endometrium of women with endometriosis
Ghazal S, McKinnon B, Zhou J, Mueller M, Men Y, Yang L, Mueller M, Flannery C, Huang Y, Taylor HS. H19 lncRNA alters stromal cell growth via IGF signaling in the endometrium of women with endometriosis. EMBO Molecular Medicine 2015, 7: 996-1003. PMID: 26089099, PMCID: PMC4551339, DOI: 10.15252/emmm.201505245.Peer-Reviewed Original ResearchConceptsChronic pelvic painReproductive-aged womenEndometrium of womenEndometrial stromal cellsStromal cell growthEndometrial preparationPelvic painEutopic endometriumAged womenEndometriosisNormal controlsStromal cellsH19 expressionImpact fertilityMolecular spongeH19/letNovel therapeuticsReduced proliferationInfertilityWomenEndometriumTurn inhibitsMicroRNA let-7Molecular mechanismsCell growthChemoattraction of bone marrow-derived stem cells towards human endometrial stromal cells is mediated by estradiol regulated CXCL12 and CXCR4 expression
Wang X, Mamillapalli R, Mutlu L, Du H, Taylor HS. Chemoattraction of bone marrow-derived stem cells towards human endometrial stromal cells is mediated by estradiol regulated CXCL12 and CXCR4 expression. Stem Cell Research 2015, 15: 14-22. PMID: 25957946, PMCID: PMC5001152, DOI: 10.1016/j.scr.2015.04.004.Peer-Reviewed Original ResearchConceptsHuman endometrial stromal cellsBone marrow cellsEndometrial stromal cellsCXCR4 expressionEndometrial cellsBM cellsCXCL12/CXCR4 expressionStromal cellsBone marrow-derived stem cellsMarrow-derived stem cellsHuman endometrial cellsStem cellsEndometrial disordersCXCL12 receptorCXCR4 antagonistCXCL12 expressionChemokine CXCL12Uterine endometriumCells engraftBone marrowEndometriumMarrow cellsStem cell migrationCXCR4CXCL12
2013
Atypical Expression of COX-2, StAR, CYP19A1 and Apoptotic Regulators in CD90 Positive Endometrial Stromal Cells from Women with Endometriosis
Kadalmani B, Taylor H, Krikun G, Palanivel K. Atypical Expression of COX-2, StAR, CYP19A1 and Apoptotic Regulators in CD90 Positive Endometrial Stromal Cells from Women with Endometriosis. Journal Of Endometriosis And Pelvic Pain Disorders 2013, 5: 77-85. DOI: 10.5301/je.5000149.Peer-Reviewed Original ResearchProgenitor stem cell populationEndometrial stromal cellsCyclo-oxygenase-2Stromal cellsStem cell populationProtein levelsPro-apoptotic moleculesAnti-apoptotic moleculesSteroidogenic acute regulatory proteinSingle cell cloningProgenitor stem cellsStem cell-like propertiesRegulatory proteinsEctopic survivalColony forming capacityApoptotic regulatorsExpression patternsAcute regulatory proteinCell-like propertiesApoptotic genesSteroidogenic genesEndometrial cellsDiminished apoptosisGenesQRT-PCR
2012
Blockade of transforming growth factor β (TGF-β) restores markers of endometrial receptivity in fibroid-exposed endometrial stromal cells (esc)
Doherty L, Taylor H. Blockade of transforming growth factor β (TGF-β) restores markers of endometrial receptivity in fibroid-exposed endometrial stromal cells (esc). Fertility And Sterility 2012, 98: s61. DOI: 10.1016/j.fertnstert.2012.07.216.Peer-Reviewed Original ResearchProgesterone-dependent regulation of endometrial cannabinoid receptor type 1 (CB1-R) expression is disrupted in women with endometriosis and in isolated stromal cells exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)
Resuehr D, Glore DR, Taylor HS, Bruner-Tran KL, Osteen KG. Progesterone-dependent regulation of endometrial cannabinoid receptor type 1 (CB1-R) expression is disrupted in women with endometriosis and in isolated stromal cells exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Fertility And Sterility 2012, 98: 948-956.e1. PMID: 22789143, PMCID: PMC3462249, DOI: 10.1016/j.fertnstert.2012.06.009.Peer-Reviewed Original ResearchConceptsEndometrial stromal cellsEndometrial tissueStromal cellsCannabinoid receptor type 1 expressionProgesterone-dominated secretory phaseMRNA expressionAnti-inflammatory actionMessenger RNATetrachlorodibenzo-p-dioxin (TCDD) exposureHuman endometrial tissueProgesterone receptor antagonistType 1 expressionSteroid-induced expressionProgesterone-dependent regulationEndometrial biopsyReceptor antagonistCannabinoid signalingHuman endometriumMedical CenterMAIN OUTCOMESecretory phaseControl donorsEndometriosisDifferentiation-related expressionExposure disruptsSimvastatin Decreases Invasiveness of Human Endometrial Stromal Cells1
Sokalska A, Cress A, Bruner-Tran KL, Osteen KG, Taylor HS, Ortega I, Duleba AJ. Simvastatin Decreases Invasiveness of Human Endometrial Stromal Cells1. Biology Of Reproduction 2012, 87: 2, 1-6. PMID: 22492974, PMCID: PMC3406552, DOI: 10.1095/biolreprod.111.098806.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell AdhesionEndometriosisEndometriumFemaleGene ExpressionHumansHyaluronan ReceptorsHydroxymethylglutaryl-CoA Reductase InhibitorsMatrix Metalloproteinase 2Matrix Metalloproteinase 3MiceMice, NudePolyisoprenyl PhosphatesPrenylationSesquiterpenesSimvastatinStromal CellsTissue Inhibitor of Metalloproteinase-2ConceptsEffect of simvastatinMatrix metalloproteinase-2Metalloproteinase-2Human endometrial stromal cellsEndometrial stromal cellsNude mouse modelConcentration-dependent reductionInhibition of HMGCREffects of GGPPInhibition of geranylgeranylationEndometrial implantsEndometrial stromaSimvastatin treatmentMouse modelAnimal modelsTissue inhibitorTIMP2 mRNASimvastatinDecrease invasivenessDecrease proliferationStromal cellsPresence of GGppCell invasivenessMRNA levelsEndometriosisA polymorphism in a let‐7 microRNA binding site of KRAS in women with endometriosis
Grechukhina O, Petracco R, Popkhadze S, Massasa E, Paranjape T, Chan E, Flores I, Weidhaas JB, Taylor HS. A polymorphism in a let‐7 microRNA binding site of KRAS in women with endometriosis. EMBO Molecular Medicine 2012, 4: 206-217. PMID: 22307873, PMCID: PMC3376847, DOI: 10.1002/emmm.201100200.Peer-Reviewed Original ResearchConceptsEndometrial stromal cellsKRAS-variantCultured endometrial stromal cellsStromal cellsAbnormal endometrial growthDe novo endometriosisProgesterone receptor levelsRelatives of womenEndometrial xenograftsKRAS resultsLCS6 polymorphismEndometrial growthReproductive ageKRAS mutationsReceptor levelsMurine modelEndometriosisEndometriosis riskControl populationVariant allelesKRAS mRNAProtein expressionKRASWomenKRAS proteinFKBP4 is regulated by HOXA10 during decidualization and in endometriosis
Yang H, Zhou Y, Edelshain B, Schatz F, Lockwood CJ, Taylor HS. FKBP4 is regulated by HOXA10 during decidualization and in endometriosis. Reproduction 2012, 143: 531-538. PMID: 22279148, DOI: 10.1530/rep-11-0438.Peer-Reviewed Original ResearchConceptsHuman endometrial stromal cellsFKBP4 expressionFKBP5 expressionTreatment of hESCCultured human endometrial stromal cellsIGFBP1 expressionEndometrium of womenProtein levelsEndometrial stromal cellsLate proliferative phaseHOXA10 knockdownHOXA10 regulationImpaired decidualizationFertile womenEutopic endometriumMenstrual cycleSecretory phaseEndometriosisDecidualizationHOXA10 expressionProliferative phaseStromal cellsMRNA expressionFKBP5FKBP4
2011
MicroRNA 135 Regulates HOXA10 Expression in Endometriosis
Petracco R, Grechukhina O, Popkhadze S, Massasa E, Zhou Y, Taylor HS. MicroRNA 135 Regulates HOXA10 Expression in Endometriosis. The Journal Of Clinical Endocrinology & Metabolism 2011, 96: e1925-e1933. PMID: 21956427, PMCID: PMC3232619, DOI: 10.1210/jc.2011-1231.Peer-Reviewed Original ResearchConceptsEndometrium of womenHOXA10 expressionHOXA10 regulationB expressionProliferative phaseEndometrial stromal cellsUniversity Medical CenterRegulation of HOXA10Time of ovulationMicroRNA-135Endometrial biopsyEndometrial receptivityMCF-7 cellsEndometrial samplesMenstrual cycleLuteal phaseMedical CenterSex steroidsStudy interventionEndometriosisSecretory phaseHOXA10 mRNAMicroRNA-135aStromal cellsEndometrium
2010
HOXA10 Inhibits Kruppel-Like Factor 9 Expression in the Human Endometrial Epithelium1
Du H, Sarno J, Taylor HS. HOXA10 Inhibits Kruppel-Like Factor 9 Expression in the Human Endometrial Epithelium1. Biology Of Reproduction 2010, 83: 205-211. PMID: 20463357, PMCID: PMC2907284, DOI: 10.1095/biolreprod.110.083980.Peer-Reviewed Original ResearchConceptsKruppel-like factor 9Endometrial epithelial cellsProgesterone receptorEndometrial epitheliumKLF9 expressionEpithelial cellsStromal cellsHuman endometrial epithelial cellsReproductive-age womenKLF9 mRNASteroid responsivenessEndometrial tissuePgR expressionSecretory phase endometrial epitheliumMenstrual cycleProgesterone actionProgesterone responsivenessSex steroidsSecretory phaseProliferative phaseProtein expressionFactor 9Reporter assaysHOXA10EpitheliumEndothelin Type A Receptor (ETA) Expression Is Regulated by HOXA10 in Human Endometrial Stromal Cells
Penna IA, Du H, Kallen AN, Taylor HS. Endothelin Type A Receptor (ETA) Expression Is Regulated by HOXA10 in Human Endometrial Stromal Cells. Reproductive Sciences 2010, 17: 471-476. PMID: 20371740, PMCID: PMC3107845, DOI: 10.1177/1933719110361961.Peer-Reviewed Original ResearchConceptsHuman endometrial stromal cell lineEndometrial stromal cellsEndometrial stromal cell lineFirst trimester decidual cellsStromal cellsHuman endometrial stromal cellsEndometrial epithelial cell lineHuman endometrial epithelial cell lineFirst trimester deciduaVascular smooth muscle cellsReverse transcriptase-polymerase chain reactionQuantitative reverse transcriptase-polymerase chain reactionTranscriptase-polymerase chain reactionSmooth muscle cellsCell linesStromal cell growthG protein-coupled receptorsReproductive-age individualsEndometrial biopsyProtein-coupled receptorsEndometrial receptivityNormal endometriumDecidual samplesElective terminationEpithelial cell line3-Phosphoglycerate dehydrogenase expression is regulated by HOXA10 in murine endometrium and human endometrial cells
Du H, Vitiello D, Sarno JL, Taylor HS. 3-Phosphoglycerate dehydrogenase expression is regulated by HOXA10 in murine endometrium and human endometrial cells. Reproduction 2010, 139: 237-245. PMID: 19778996, PMCID: PMC3107855, DOI: 10.1530/rep-08-0376.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnimalsCell LineCells, CulturedEndometriumEpithelial CellsFemaleGene Expression Regulation, EnzymologicHomeobox A10 ProteinsHomeodomain ProteinsHumansImmunohistochemistryMenstrual CycleMiceOligonucleotide Array Sequence AnalysisPhosphoglycerate DehydrogenasePregnancyRNA, MessengerRNA, Small InterferingStromal CellsTransfectionConceptsSerine biosynthesisRegulatory relationshipsHOXA10 regulationProtein synthesisPHGDH expressionReal-time PCR resultsStromal cellsCellular differentiationTarget genesHuman endometrial cellsPHGDHMRNA expressionHuman endometrial stromal cellsDe novoWestern blot resultsDehydrogenase expressionBiosynthesisHOXA10Epithelial cellsHOXA10 siRNARegulationExpressionEndometrial stromal cellsHOXA10 expressionBlot results
2008
GnRH antagonists may affect endometrial receptivity
Rackow BW, Kliman HJ, Taylor HS. GnRH antagonists may affect endometrial receptivity. Fertility And Sterility 2008, 89: 1234-1239. PMID: 18410932, PMCID: PMC2699407, DOI: 10.1016/j.fertnstert.2007.04.060.Peer-Reviewed Original ResearchConceptsGnRH antagonistEndometrial stromal cellsEndometrial receptivityHOXA10 protein expressionHOXA10 expressionGnRH agonistControl subjectsProspective case-control studyStromal cellsEndometrial HOXA10 expressionPipelle endometrial biopsyProtein expressionSpontaneous LH surgeCase-control studyAcademic medical centerNatural cycleOvarian hyperstimulationRecombinant FSHEndometrial biopsyHCG administrationUntreated cyclesEndometrial glandsLH surgeMedical CenterMAIN OUTCOME
2007
Demonstration of Multipotent Stem Cells in the Adult Human Endometrium by In Vitro Chondrogenesis
Wolff EF, Wolff AB, Du H, Taylor HS. Demonstration of Multipotent Stem Cells in the Adult Human Endometrium by In Vitro Chondrogenesis. Reproductive Sciences 2007, 14: 524-533. PMID: 17959881, DOI: 10.1177/1933719107306896.Peer-Reviewed Original ResearchConceptsEndometrial stromal cellsMultipotent stem cellsFallopian tubeType II collagenStem cellsReproductive-aged womenHuman articular cartilageEndometrial stem cellsAdult human endometriumII collagenMultilineage differentiationArticular cartilageBenign diseaseEndometrial tissueExtramedullary tissuesHuman endometriumCell pelletsEndometriumChondrogenic mediumStromal cellsLigament cellsSulfated glycosaminoglycansGrowth factorProgenitor cellsCell typesALTERED ENDOMETRIAL GENE EXPRESSION IN A BABOON MODEL OF ENDOMETRIOSIS
bas A, Hastings J, Jackson K, Giudice L, Kim J, Taylor H, Zhang X, Ho S. ALTERED ENDOMETRIAL GENE EXPRESSION IN A BABOON MODEL OF ENDOMETRIOSIS. Biology Of Reproduction 2007, 77: 71-72. DOI: 10.1093/biolreprod/77.s1.71b.Peer-Reviewed Original ResearchGene expressionEutopic endometriumEndometriosis modelEndometriotic samplesStromal cellsDifferential gene expressionP actionNon-human primate modelSteroid receptor distributionChronic pelvic painLevel of genesWindow of implantationLevel of methylationWindow of receptivityConsecutive menstrual cyclesEndometrial gene expressionInduction of diseaseGlandular epithelial cellsBisulfite sequencingMolecular playersEpigenetic changesTransient dysregulationPelvic painEndometrial morphologyProgesterone resistance
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