2025
Stem cells and female reproduction: endometrial physiology, disease and therapy
Cevik E, Mamillapalli R, Taylor H. Stem cells and female reproduction: endometrial physiology, disease and therapy. Stem Cells 2025, 43: sxaf016. PMID: 40317260, DOI: 10.1093/stmcls/sxaf016.Peer-Reviewed Original ResearchConceptsBone marrow-derived mesenchymal stem cellsStem cellsKnowledge of stem cell biologyStem cell-based therapiesEngraftment of stem cellsRecurrent pregnancy lossImprove pregnancy outcomesEndometrial progenitor cellsMinimally invasive techniquesProgenitor stem cellsCell-based therapiesStem cell biologyAsherman's syndromeCells to areasPotential therapeutic avenuePregnancy outcomesThin endometriumHuman endometriumMarrow-derived mesenchymal stem cellsTargeted therapyEndometrial repairEndometrial regenerationPregnancy lossImplant failureInvasive techniques
2022
Therapeutic role of uterine-derived stem cells in acute kidney injury
Mamillapalli R, Cho S, Mutlu L, Taylor HS. Therapeutic role of uterine-derived stem cells in acute kidney injury. Stem Cell Research & Therapy 2022, 13: 107. PMID: 35279204, PMCID: PMC8917641, DOI: 10.1186/s13287-022-02789-0.Peer-Reviewed Original ResearchConceptsSerum creatinine levelsAKI miceIschemic AKIKidney functionUterine stem cellsKidney injuryCreatinine levelsPositive cellsBilateral renal ischemia-reperfusion injurySurvival rateLower serum creatinine levelsRenal ischemia-reperfusion injuryHigher survival rateBackgroundAcute kidney injuryPrevalence of AKIStem cellsAcute kidney injuryVascular regenerationIschemia-reperfusion injuryKaplan-Meier methodDefinitive treatment optionPromising new therapyExpression of CXCL12CD31-positive cellsUnpaired t-test
2021
Characterization of Bone Marrow Progenitor Cell Uterine Engraftment and Transdifferentiation
Mamillapalli R, Mutlu L, Taylor HS. Characterization of Bone Marrow Progenitor Cell Uterine Engraftment and Transdifferentiation. Reproductive Sciences 2021, 29: 2382-2390. PMID: 34515983, DOI: 10.1007/s43032-021-00738-5.Peer-Reviewed Original ResearchConceptsBone marrow-derived stem cellsRecipient miceBone marrow-derived cellsProgenitor cellsBone marrow transplantMarrow-derived cellsMarrow-derived stem cellsSpecific uterine cell typesBone marrow-derived progenitorsMarrow-derived progenitorsUterine cell typesUpregulation of markersCell surface markersStem cellsSpecific stem cell markersStem cell markersCell typesUterine repairMarrow transplantStem cell componentUterine tissueMurine modelMaintenance of fertilityDifferentiation of BMSCsCell markers
2020
Endometriosis Cell Proliferation Induced by Bone Marrow Mesenchymal Stem Cells
Chen P, Mamillapalli R, Habata S, Taylor HS. Endometriosis Cell Proliferation Induced by Bone Marrow Mesenchymal Stem Cells. Reproductive Sciences 2020, 28: 426-434. PMID: 32812213, DOI: 10.1007/s43032-020-00294-4.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCase-Control StudiesCDC2 Protein KinaseCell ProliferationCells, CulturedCoculture TechniquesDisease Models, AnimalEndometriosisEndometriumFemaleHumansMesenchymal Stem Cell TransplantationMesenchymal Stem CellsMice, Inbred C57BLParacrine CommunicationSignal TransductionStromal CellsConceptsBone marrow-derived stem cellsCell proliferationEndometrial cellsEstrogen-dependent gynecological disorderPrimary endometrial stromal cellsEndometrial stromal cell proliferationEndometriosis cell proliferationReproductive-aged womenEndometrial stromal cellsNormal endometrial cellsEndometrial cell proliferationMarrow-derived stem cellsNovel therapeutic strategiesStromal cell proliferationBone marrow mesenchymal stem cellsStem cellsSignificant clonal expansionMarrow mesenchymal stem cellsPelvic painEndometriotic lesionsEndometriosis growthGynecological disordersEndometriosis cell linesMouse modelEndometriosis
2019
Uterine Cells Improved Ovarian Function in a Murine Model of Ovarian Insufficiency
Reig A, Mamillapalli R, Coolidge A, Johnson J, Taylor HS. Uterine Cells Improved Ovarian Function in a Murine Model of Ovarian Insufficiency. Reproductive Sciences 2019, 26: 1633-1639. PMID: 31530098, PMCID: PMC6949960, DOI: 10.1177/1933719119875818.Peer-Reviewed Original ResearchConceptsEndometrial mesenchymal stem cellsPrimary ovarian insufficiencyOvarian functionOvarian insufficiencyMurine modelSerum anti-Müllerian hormone concentrationsAnti-Müllerian hormone concentrationsStem cellsStem cell therapyOvarian dysfunctionUterine cell suspensionsHormone concentrationsMesenchymal stem cellsUterine cellsChemotherapyYoung womenCell therapyMiceOocyte poolIncreased numberWomenHigher body massSignificant increaseInsufficiencyPupsCD34+KLF4+ Stromal Stem Cells Contribute to Endometrial Regeneration and Repair
Yin M, Zhou HJ, Lin C, Long L, Yang X, Zhang H, Taylor H, Min W. CD34+KLF4+ Stromal Stem Cells Contribute to Endometrial Regeneration and Repair. Cell Reports 2019, 27: 2709-2724.e3. PMID: 31141693, PMCID: PMC6548470, DOI: 10.1016/j.celrep.2019.04.088.Peer-Reviewed Original ResearchConceptsEndometrial regenerationEndometrial epitheliumStem cellsLocal stem cellsEndometrial repairHuman endometriumUterine hyperplasiaStromal stem cellsCD34Regenerative capacitySM22αEpitheliumCellsProliferative signalingTranscriptional activityRepairKLF4EndometriumHyperplasiaERαProtein SUMOylationRegeneration modelMiceAdipocyte alterations in endometriosis: reduced numbers of stem cells and microRNA induced alterations in adipocyte metabolic gene expression
Zolbin MM, Mamillapalli R, Nematian SE, Goetz T, Taylor HS. Adipocyte alterations in endometriosis: reduced numbers of stem cells and microRNA induced alterations in adipocyte metabolic gene expression. Reproductive Biology And Endocrinology 2019, 17: 36. PMID: 30982470, PMCID: PMC6463663, DOI: 10.1186/s12958-019-0480-0.Peer-Reviewed Original ResearchConceptsBody mass indexFat metabolismFat tissueMouse modelAdipose tissueMetabolic gene expressionLower body mass indexOld female C57BL/6 miceAdipocytes of womenMicroRNA let‑7bSerum of womenReproductive-aged womenEffect of endometriosisFemale C57BL/6 miceStem cellsAdipose-derived mesenchymal stem cellsBrown adipocyte differentiationInhibitors of microRNAsStem cell contentMass indexMetabolic abnormalitiesC57BL/6 miceInflammatory disordersIL-6Insulin sensitivity
2018
Uterine stem cells: from basic research to advanced cell therapies
Santamaria X, Mas A, Cervelló I, Taylor H, Simon C. Uterine stem cells: from basic research to advanced cell therapies. Human Reproduction Update 2018, 24: 673-693. PMID: 30239705, DOI: 10.1093/humupd/dmy028.Peer-Reviewed Original ResearchConceptsBone marrow-derived stem cellsMyometrial stem cellsAtrophic endometriumAsherman's syndromeUterine pathologyCell therapyStem cellsMarrow-derived stem cellsNovel therapeutic approachesTumor-initiating cellsStem/progenitor cellsStem cell therapyUterine stem cellsUterine transplantationHuman endometriumUterine physiologyUterine leiomyomaTherapeutic approachesMouse modelHuman uterusAdvanced stem cell therapyAnimal modelsBone marrowEndometriumAutologous sourceTherapeutic strategies involving uterine stem cells in reproductive medicine
Simoni M, Taylor HS. Therapeutic strategies involving uterine stem cells in reproductive medicine. Current Opinion In Obstetrics & Gynecology 2018, 30: 209-216. PMID: 29652725, DOI: 10.1097/gco.0000000000000457.Peer-Reviewed Original ResearchConceptsStem cell mobilizationMultipotent stem cellsEndometrial defectAsherman's syndromeStem cellsStem cell biologyEndometrial receptivity defectsLow estrogen levelsBone marrow-derived multipotent stem cellsInjury-induced expressionUterine stem cellsEndometriosis therapyProgenitor stem cellsEndometrial diseaseEstrogen levelsNormal endometriumOverwhelming injuryStem cell recruitmentMenstrual cycleEndometrial cellsStem cell traffickingReservoir of cellsCell recruitmentChemokine CXCL12Therapeutic strategiesHematogenous Dissemination of Mesenchymal Stem Cells from Endometriosis
Li F, Alderman MH, Tal A, Mamillapalli R, Coolidge A, Hufnagel D, Wang Z, Neisani E, Gidicsin S, Krikun G, Taylor HS. Hematogenous Dissemination of Mesenchymal Stem Cells from Endometriosis. Stem Cells 2018, 36: 881-890. PMID: 29450941, PMCID: PMC5992028, DOI: 10.1002/stem.2804.Peer-Reviewed Original ResearchConceptsSerum CXCL12 levelsCXCL12 levelsEndometrial tissueEndometriosis lesionsHematogenous disseminationMesenchymal stem cell biomarkersCXCL12/CXCR4 axisStem cellsTreatment of endometriosisSham control miceEndometrial stem cellsHematopoietic stem cell markersStem cell biomarkersStem cell markersSpontaneous endometriosisRetrograde menstruationControl miceExperimental endometriosisRecipient miceCXCR4 axisLung tissueEndometriosisPeritoneal cavityDsRed miceBlood of animals
2017
Medical Therapies for Endometriosis Differentially Inhibit Stem Cell Recruitment
Sahin Ersoy GS, Zolbin MM, Cosar E, Mamillapalli R, Taylor HS. Medical Therapies for Endometriosis Differentially Inhibit Stem Cell Recruitment. Reproductive Sciences 2017, 24: 818-823. PMID: 28256937, DOI: 10.1177/1933719116682879.Peer-Reviewed Original ResearchConceptsBone marrow-derived stem cellsMedroxyprogesterone acetateEstrogen deprivationEndometriosis lesionsStem cell recruitmentCell recruitmentLesions of endometriosisGreen fluorescent protein miceWeeks of treatmentBone marrow transplantLong-term treatmentMarrow-derived stem cellsStem cellsProgestin medroxyprogesterone acetateLong-term regressionBone marrow stem cellsStem cell engraftmentMarrow stem cellsProgestin therapyEndometriosis treatmentLesion regressionMedical therapyEndometriotic lesionsMarrow transplantC57BL/6 miceBone Marrow Stem Cell Chemotactic Activity Is Induced by Elevated CXCl12 in Endometriosis
Moridi I, Mamillapalli R, Cosar E, Ersoy GS, Taylor HS. Bone Marrow Stem Cell Chemotactic Activity Is Induced by Elevated CXCl12 in Endometriosis. Reproductive Sciences 2017, 24: 526-533. PMID: 27729562, PMCID: PMC5933203, DOI: 10.1177/1933719116672587.Peer-Reviewed Original ResearchConceptsEutopic endometriumEndometriotic lesionsChemotactic activityCXCR4 messenger RNAProtein expressionTreatment of endometriosisCXCR4 protein expressionStem cellsExpression of CXCL12CXCL12/CXCR4Transwell chamber migrationCXCL12 protein expressionEnzyme-linked immunosorbentBone marrow stem cellsBone marrow cellsMouse bone marrow stem cellsMarrow stem cellsEndometrial tissueControl endometriumGynecological disordersEndometriosisEndometriumChamber migrationCondition mediumCXCL12
2016
Endometriosis and Stem Cell Trafficking
Pluchino N, Taylor HS. Endometriosis and Stem Cell Trafficking. Reproductive Sciences 2016, 23: 1616-1619. PMID: 27821558, DOI: 10.1177/1933719116671219.Peer-Reviewed Original ResearchConceptsEndometriotic lesionsStem cellsCell traffickingPresence of endometriosisProgression of endometriosisAdult stem cellsEpithelial fateEndometrial physiologyEutopic endometriumStem cell traffickingDysfunctional endometriumEndometriosisMolecular mechanismsCell mobilityBlood circulationNew targetsEndometriumUterusLesionsTraffickingCritical roleCellsMajor roleEngraftmentBMDSC
2015
The Role of Stem Cells in the Etiology and Pathophysiology of Endometriosis
Hufnagel D, Li F, Cosar E, Krikun G, Taylor HS. The Role of Stem Cells in the Etiology and Pathophysiology of Endometriosis. Seminars In Reproductive Medicine 2015, 33: 333-340. PMID: 26375413, PMCID: PMC4986990, DOI: 10.1055/s-0035-1564609.Peer-Reviewed Original ResearchConceptsStem cellsStem cell populationProgenitor stem cellsStem cell traffickingCyclic regenerationPool of cellsCell mobilityBone marrow-derived stem cellsMarrow-derived stem cellsDynamic organRecent characterizationUnrestrained growthCell populationsCell traffickingEctopic sitesCellsRapid regenerationHuman endometriumRegenerationPathologic roleGrowthEndometriosis interferesPathophysiology of endometriosisDevelopment of endometriosisTraffickingChemoattraction of bone marrow-derived stem cells towards human endometrial stromal cells is mediated by estradiol regulated CXCL12 and CXCR4 expression
Wang X, Mamillapalli R, Mutlu L, Du H, Taylor HS. Chemoattraction of bone marrow-derived stem cells towards human endometrial stromal cells is mediated by estradiol regulated CXCL12 and CXCR4 expression. Stem Cell Research 2015, 15: 14-22. PMID: 25957946, PMCID: PMC5001152, DOI: 10.1016/j.scr.2015.04.004.Peer-Reviewed Original ResearchConceptsHuman endometrial stromal cellsBone marrow cellsEndometrial stromal cellsCXCR4 expressionEndometrial cellsBM cellsCXCL12/CXCR4 expressionStromal cellsBone marrow-derived stem cellsMarrow-derived stem cellsHuman endometrial cellsStem cellsEndometrial disordersCXCL12 receptorCXCR4 antagonistCXCL12 expressionChemokine CXCL12Uterine endometriumCells engraftBone marrowEndometriumMarrow cellsStem cell migrationCXCR4CXCL12The Endometrium as a Source of Mesenchymal Stem Cells for Regenerative Medicine1
Mutlu L, Hufnagel D, Taylor HS. The Endometrium as a Source of Mesenchymal Stem Cells for Regenerative Medicine1. Biology Of Reproduction 2015, 92: 138, 1-11. PMID: 25904012, PMCID: PMC4652610, DOI: 10.1095/biolreprod.114.126771.Peer-Reviewed Original ResearchConceptsMesenchymal stem cellsStem cellsEmbryonic stem cellsAdult stem cellsPluripotent stem cellsPossibility of regeneratingRegenerative medicineTissue regenerationMature cell typesEndometrial stem cellsCell therapyDifferentiation capacityHematopoietic stem cellsCell typesNew frontierNovel sourceCurrent understandingCellsTherapeutic potential
2014
Identification of Putative Fallopian Tube Stem Cells
Snegovskikh V, Mutlu L, Massasa E, Taylor HS. Identification of Putative Fallopian Tube Stem Cells. Reproductive Sciences 2014, 21: 1460-1464. PMID: 25305130, PMCID: PMC4231131, DOI: 10.1177/1933719114553448.Peer-Reviewed Original ResearchConceptsLabel-retaining cellsStem cellsStem/progenitor cell populationsStem cell nicheProgenitor cell populationsDAPI-stained nucleiStem cell reservePutative stem cellsCell nicheMultiple tissuesProgenitor cellsConfocal microscopyCell populationsImmunofluorescence studiesReproductive tractSection tissueCellsTissue regenerationOviductCell reserveTissueRegenerationNichePopulationNucleusEndometrial stem cell transplantation in MPTP‐ exposed primates: an alternative cell source for treatment of Parkinson's disease
Wolff EF, Mutlu L, Massasa EE, Elsworth JD, Redmond D, Taylor HS. Endometrial stem cell transplantation in MPTP‐ exposed primates: an alternative cell source for treatment of Parkinson's disease. Journal Of Cellular And Molecular Medicine 2014, 19: 249-256. PMID: 25283241, PMCID: PMC4288367, DOI: 10.1111/jcmm.12433.Peer-Reviewed Original ResearchConceptsEndometrium-derived stem cellsParkinson's diseaseTyrosine hydroxylaseStem cellsDopamine metabolite concentrationsStem cell transplantationTH-positive cellsNeuron-like morphologyTransplanted sideNeuronal lossCell transplantationDopaminergic neuronsSubstantia nigraPrimate modelCell replacement therapyMonkey modelTherapeutic benefitAlternative cell sourcePositive cellsCellular therapyNeurodegenerative diseasesDiseaseTherapyEase of collectionMetabolite concentrationsEndometrial Stem Cells as Potential Cures for Human Diseases
Krikun G, Taylor H. Endometrial Stem Cells as Potential Cures for Human Diseases. 2014, 39-43. DOI: 10.1007/978-1-4471-6542-2_5.Peer-Reviewed Original ResearchAdult stem cellsImmediate therapeutic applicationStem cellsMultipotent mesenchymal stem cellsTeratoma formationGenetic transformationMesenchymal stem cellsBeta-like cellsTherapeutic applicationsEndometrial stem cellsMedical potentialSpecific culture techniquesDifferentiated cell typesEngenders optimismClinical applicationTissue repairPancreatic beta-like cellsHuman endometriumReliable therapyApplicationsPotential cureCatastrophic illnessUndifferentiated cellsCulture techniquesPreliminary dataEndometriosis Impairs Bone Marrow-Derived Stem Cell Recruitment to the Uterus Whereas Bazedoxifene Treatment Leads to Endometriosis Regression and Improved Uterine Stem Cell Engraftment
Sakr S, Naqvi H, Komm B, Taylor HS. Endometriosis Impairs Bone Marrow-Derived Stem Cell Recruitment to the Uterus Whereas Bazedoxifene Treatment Leads to Endometriosis Regression and Improved Uterine Stem Cell Engraftment. Endocrinology 2014, 155: 1489-1497. PMID: 24484171, PMCID: PMC3959601, DOI: 10.1210/en.2013-1977.Peer-Reviewed Original ResearchConceptsBZA/CEConjugated estrogensEndometriosis lesionsStem cell recruitmentCell engraftmentStem cell engraftmentCell recruitmentExperimental endometriosisEutopic endometriumUterine endometriumBone marrowSelective estrogen receptor modulator bazedoxifeneStem cellsMesenchymal stem cell engraftmentLesions of endometriosisMale bone marrowUteri of animalsBazedoxifene treatmentCell nuclear antigenEndometriosis interferesOvarian stimulationVehicle treatmentEndometrial functionNormal endometriumOvarian weight
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