2025
Impact of peritoneal macrophage depletion on endometriotic lesion development in a mouse model
Stratopoulou C, Cacciottola L, Gawde N, Ngombo A, Brusa D, Donnez J, Taylor H, Dolmans M. Impact of peritoneal macrophage depletion on endometriotic lesion development in a mouse model. Journal Of Endometriosis And Uterine Disorders 2025, 10: 100113. DOI: 10.1016/j.jeud.2025.100113.Peer-Reviewed Original ResearchMacrophage depletionEndometriotic lesionsTreated miceMacrophage accumulationMouse modelVascular endothelial growth factor immunostainingEndometriosis developmentQuantification of immune cellsFlow cytometryMouse model of endometriosisClodronate-containing liposomesKi67-positive proliferating cellsNovel therapeutic optionsRate of fibrosisModel of endometriosisTUNEL-positive apoptotic cellsLevels of fibrosisPathogenesis of endometriosisReproductive-age womenMasson's trichrome stainingEndometriotic lesion developmentEnhanced cell deathPlacebo-ControlledUterine fragmentsT cellsEvaluating the Effect of Epigallocatechin Gallate (EGCG) in Reducing Folate Levels in Reproductive Aged Women by MTHFR and DHFR Genotype in Combination With Letrozole or Clomiphene
Johnson J, Siblini H, Al‐Hendy A, Segars J, González F, Taylor H, Singh B, Carson S, Christman G, Huang H, Dangi B, Zhang H. Evaluating the Effect of Epigallocatechin Gallate (EGCG) in Reducing Folate Levels in Reproductive Aged Women by MTHFR and DHFR Genotype in Combination With Letrozole or Clomiphene. Clinical And Translational Science 2025, 18: e70189. PMID: 40077973, PMCID: PMC11903501, DOI: 10.1111/cts.70189.Peer-Reviewed Original ResearchConceptsEpigallocatechin-3-gallateFolate levelsUterine fibroidsClinical trialsGreen tea extractAssociated with folate deficiencyPresence of MTHFRWomen of Childbearing AgeSerum folate levelsReduced folate levelsActive clinical trialsReproductive-age womenEffect of epigallocatechin gallateDHFR genotypeDHFR polymorphismTea extractDaily doseClomiphene citrateUnexplained infertilityFolate deficiencyChildbearing ageClinical studiesTreated womenFibroidsLetrozole
2024
Progesterone receptor status predicts aggressiveness of human endometriotic lesions in murine avatars
Flores V, Sahin C, Taylor H. Progesterone receptor status predicts aggressiveness of human endometriotic lesions in murine avatars. F&S Science 2024, 6: 65-72. PMID: 39393571, DOI: 10.1016/j.xfss.2024.10.004.Peer-Reviewed Original ResearchProgestin-based therapyAggressive forms of endometriosisPR lesionsProgesterone receptorGnRH antagonistMedroxyprogesterone acetatePR statusEndometriotic lesionsAggressive formResponse to MPAResponse to medical therapyPost-treatment sizeProgesterone receptor statusHuman endometriotic lesionsResponse to progestinsChronic gynecological diseaseDaily subcutaneous injectionsReproductive-age womenMouse xenograft modelResponse to medicationEndometrioma lesionsReceptor statusHormone suppressionPR expressionClinical responseFibroids and unexplained infertility treatment with epigallocatechin gallate: a natural compound in green tea (FRIEND) – protocol for a randomised placebo-controlled US multicentre clinical trial of EGCG to improve fertility in women with uterine fibroids
Al-Hendy A, Segars J, Taylor H, González F, Siblini H, Zamah M, Alkelani H, Singh B, Flores V, Christman G, Johnson J, Huang H, Zhang H. Fibroids and unexplained infertility treatment with epigallocatechin gallate: a natural compound in green tea (FRIEND) – protocol for a randomised placebo-controlled US multicentre clinical trial of EGCG to improve fertility in women with uterine fibroids. BMJ Open 2024, 14: e078989. PMID: 38216200, PMCID: PMC10806662, DOI: 10.1136/bmjopen-2023-078989.Peer-Reviewed Original ResearchConceptsUnexplained infertilityIntrauterine inseminationInstitutional review boardCumulative live birth rateUterine fibroidsLive birth rateCause of infertilityFood and Drug AdminstrationGonadotropin hormone-releasing hormoneGreen tea extractDouble-blind clinical trialNon-surgical treatment optionsTimed intrauterine inseminationUterine fibroid sizeOvarian stimulationQuality of Life Questionnaire scoresHormone-releasing hormoneLocal institutional review boardInfertility treatmentNational Institute of Child HealthInstitute of Child HealthMiscarriage rateBirth rateReproductive-age womenEndometrial quality
2021
High-sensitivity C-reactive protein is not independently associated with self-reported infertility in National Health and Nutrition Examination Survey 2015–2018 data
Al-Lami RA, Taha SA, Jalloul RJ, Taylor HS. High-sensitivity C-reactive protein is not independently associated with self-reported infertility in National Health and Nutrition Examination Survey 2015–2018 data. F&S Reports 2021, 3: 63-70. PMID: 35386498, PMCID: PMC8978077, DOI: 10.1016/j.xfre.2021.12.003.Peer-Reviewed Original ResearchSelf-reported infertilityC-reactive proteinHigh-sensitivity C-reactive proteinHs-CRP valuesHs-CRPCardiovascular diseaseObesity measuresMetabolic markersHigher hs-CRP valuesNutrition Examination Survey 2015Multivariable logistic regression analysisHigh hs-CRPReproductive-age womenCross-sectional studyLogistic regression analysisHigh-density lipoproteinOdds ratio estimatesTime of studyBilateral oophorectomyInfertile womenInfertility statusRisk factorsThyroid diseaseNational HealthSensitive marker
2020
Accurate Diagnosis of Endometriosis Using Serum MicroRNAs
Moustafa S, Burn M, Mamillapalli R, Nematian S, Flores V, Taylor H. Accurate Diagnosis of Endometriosis Using Serum MicroRNAs. Obstetrical & Gynecological Survey 2020, 75: 404-406. DOI: 10.1097/ogx.0000000000000816.Peer-Reviewed Original Research
2019
miR-45la Inhibition Reduces Established Endometriosis Lesions in Mice
Li M, Zhou Y, Taylor HS. miR-45la Inhibition Reduces Established Endometriosis Lesions in Mice. Reproductive Sciences 2019, 26: 1506-1511. PMID: 31354069, DOI: 10.1177/1933719119862050.Peer-Reviewed Original ResearchConceptsMiR-451a inhibitorReproductive-age womenTreatment of endometriosisPro-inflammatory diseasesSystemic treatmentEndometriosis lesionsIL-6Chronic diseasesPromising therapyCurrent treatmentMicroRNA-451aMurine modelSex steroidsEndometriosisLesion sizeVisible lesionsMiR-451aMicroRNAs treatmentsDiseaseAltered expressionΒ-cateninTreatmentLesionsInhibitorsMultiple pathwaysEndometriosis
Flores V, Taylor H. Endometriosis. DeckerMed Family Medicine 2019 DOI: 10.2310/fm.1005.Peer-Reviewed Original ResearchPelvic painSurgical therapyGrowth of endometriosisReproductive-age womenRole of estrogenDiagnosis of endometriosisGynecologic diseaseRetrograde menstruationCommon symptomsEndometriosis managementTreatment optionsPatient preferencesAge womenEndometriosisMolecular pathwaysPainPatientsAberrant gene expressionInfertilityTherapyDiseaseGene expressionDyspareuniaEstrogenEtiologyEndometriosis
Flores V, Taylor H. Endometriosis. DeckerMed Medicine 2019 DOI: 10.2310/im.1005.Peer-Reviewed Original ResearchPelvic painSurgical therapyGrowth of endometriosisReproductive-age womenRole of estrogenDiagnosis of endometriosisGynecologic diseaseRetrograde menstruationCommon symptomsEndometriosis managementTreatment optionsPatient preferencesAge womenEndometriosisMolecular pathwaysPainPatientsAberrant gene expressionInfertilityTherapyDiseaseGene expressionDyspareuniaEstrogenEtiologyLack of an Association between a Polymorphism in the KRAS 3′ Untranslated Region (rs61764370) and Endometriosis in a Large European Case-Control Study
D'Hooghe TM, Grechukhina O, Cho S, Fassbender A, O D, Peterse D, Weidhaas J, Taylor HS. Lack of an Association between a Polymorphism in the KRAS 3′ Untranslated Region (rs61764370) and Endometriosis in a Large European Case-Control Study. Gynecologic And Obstetric Investigation 2019, 84: 575-582. PMID: 31185482, DOI: 10.1159/000500626.Peer-Reviewed Original ResearchConceptsCase-control studyGerm-line single nucleotide polymorphismsKRAS geneLarge case-control studyReproductive-age womenType of infertilityBody mass indexEuropean case-control studyKRAS 3' untranslated regionLarge European case-control studyMicroRNA-binding sitesMedical therapyPeritoneal biopsiesMass indexPeripheral bloodAge womenPolymerase chain reactionCommon disorderTreatment resistanceEndometriosisCarrier rateVariant allelesCaucasian populationGene variantsKRAS allele
2015
Integrative Analysis Reveals Regulatory Programs in Endometriosis
Yang H, Kang K, Cheng C, Mamillapalli R, Taylor HS. Integrative Analysis Reveals Regulatory Programs in Endometriosis. Reproductive Sciences 2015, 22: 1060-1072. PMID: 26134036, PMCID: PMC5933170, DOI: 10.1177/1933719115592709.Peer-Reviewed Original ResearchMeSH KeywordsCase-Control StudiesChromatin ImmunoprecipitationComputational BiologyCore Binding Factor Alpha 2 SubunitDatabases, GeneticEndometriosisEstrogen Receptor alphaEstrogen Receptor betaFemaleGene Expression ProfilingGene Expression RegulationGene Regulatory NetworksGenetic Association StudiesGenetic MarkersHepatocyte Nuclear Factor 3-betaHumansProtein BindingProtein Interaction MappingProtein Interaction MapsReceptors, AndrogenTranscription Factor AP-2Transcription, GeneticTumor Suppressor Protein p53ConceptsAndrogen receptorFunction of ARReproductive-age womenCommon gynecological diseasePathology of endometriosisEstrogen receptor βEstrogen receptor αReal-time polymerase chain reactionSuch expression changesQuantitative real-time polymerase chain reactionPolymerase chain reactionGynecological diseasesGene expressionGene Expression Omnibus databaseEndometriosisReceptor βReceptor αTranscription factors
2010
Leiomyoma Simultaneously Impair Endometrial BMP-2-Mediated Decidualization and Anticoagulant Expression through Secretion of TGF-β3
Sinclair DC, Mastroyannis A, Taylor HS. Leiomyoma Simultaneously Impair Endometrial BMP-2-Mediated Decidualization and Anticoagulant Expression through Secretion of TGF-β3. The Journal Of Clinical Endocrinology & Metabolism 2010, 96: 412-421. PMID: 21084396, PMCID: PMC3048319, DOI: 10.1210/jc.2010-1450.Peer-Reviewed Original ResearchMeSH KeywordsAdultAntithrombin IIIBlood CoagulationBone Morphogenetic Protein 2Cells, CulturedDeciduaDNA, ComplementaryEnzyme-Linked Immunosorbent AssayFemaleHumansImmunohistochemistryInfertility, FemaleLeiomyomaMenorrhagiaMiddle AgedPlasminogen Activator Inhibitor 1Reverse Transcriptase Polymerase Chain ReactionRNAStromal CellsThrombomodulinTransforming Growth Factor beta3Uterine NeoplasmsConceptsEndometrial stromal cellsAntithrombin IIIPAI-1Bone morphogenetic protein receptorTGF-β3Primary endometrial stromal cellsEffects of leiomyomaReproductive-age womenPlasminogen activator inhibitor-1Expression of HOXA10TGF-β3 treatmentEndometrial gene expressionUniversity Medical CenterLess PAI-1Activator inhibitor-1Endometrial defectQuantitative RT-PCREndometrial decidualizationMenstrual bleedingLIF expressionMiscarriage riskUterine leiomyomaMedical CenterReproductive dysfunctionCase controlEnvironmental induction of the fetal epigenome
Odom LN, Taylor HS. Environmental induction of the fetal epigenome. Expert Review Of Obstetrics & Gynecology 2010, 5: 657-664. PMID: 21297874, PMCID: PMC3032386, DOI: 10.1586/eog.10.58.Peer-Reviewed Original ResearchFetal epigenomeReproductive-age womenMaternal environmentUtero exposureBarker hypothesisHealthy adultsHealthcare providersAdult HealthVulnerable timeProfound epigenetic effectsEnvironmental exposuresFetusesEpigenetic alterationsEpigenomic alterationsExposureAlterationsNumerous studiesEpigenetic effectsFurther supportPregnancyDiseaseDNA methylationHOXA10 Inhibits Kruppel-Like Factor 9 Expression in the Human Endometrial Epithelium1
Du H, Sarno J, Taylor HS. HOXA10 Inhibits Kruppel-Like Factor 9 Expression in the Human Endometrial Epithelium1. Biology Of Reproduction 2010, 83: 205-211. PMID: 20463357, PMCID: PMC2907284, DOI: 10.1095/biolreprod.110.083980.Peer-Reviewed Original ResearchConceptsKruppel-like factor 9Endometrial epithelial cellsProgesterone receptorEndometrial epitheliumKLF9 expressionEpithelial cellsStromal cellsHuman endometrial epithelial cellsReproductive-age womenKLF9 mRNASteroid responsivenessEndometrial tissuePgR expressionSecretory phase endometrial epitheliumMenstrual cycleProgesterone actionProgesterone responsivenessSex steroidsSecretory phaseProliferative phaseProtein expressionFactor 9Reporter assaysHOXA10Epithelium
2009
Inflammation in Reproductive Disorders
Weiss G, Goldsmith LT, Taylor RN, Bellet D, Taylor HS. Inflammation in Reproductive Disorders. Reproductive Sciences 2009, 16: 216-229. PMID: 19208790, PMCID: PMC3107847, DOI: 10.1177/1933719108330087.Peer-Reviewed Original ResearchConceptsInflammatory disordersImmune responseReproductive-age womenNonspecific immune responsesImmune cell traffickingAnatomic disordersEndometrial developmentEndometrial functionEndometrial receptivityGynecologic diseaseInflammatory cytokinesAge womenImmune cellsMenstrual cycleInflammationTargeted treatmentReproductive disordersHormone productionCell traffickingInfectious diseasesNormal tissuesReproductive medicineDisordersTissue repairDisease
2006
Ovarian cryopreservation with transposition of a contralateral ovary: a combined approach for fertility preservation in women receiving pelvic radiation
Martin JR, Kodaman P, Oktay K, Taylor HS. Ovarian cryopreservation with transposition of a contralateral ovary: a combined approach for fertility preservation in women receiving pelvic radiation. Fertility And Sterility 2006, 87: 189.e5-189.e7. PMID: 17084399, DOI: 10.1016/j.fertnstert.2006.04.051.Peer-Reviewed Original ResearchConceptsReproductive-age womenPelvic radiationFertility preservationOvarian transpositionOvarian cryopreservationContralateral ovaryAge womenFuture fertility optionsLaparoscopic ovarian transpositionTertiary care hospitalSpinal cord tumorsNulligravid womenPelvic irradiationCare hospitalCord tumorsCase reportIVF centerLaparoscopic surgeryFertility optionsMAIN OUTCOMESingle ovaryWomenOvariesCryopreservationTransposition
2003
Regulation of HOXA-10 Expression by Testosterone in Vitro and in the Endometrium of Patients with Polycystic Ovary Syndrome
Cermik D, Selam B, Taylor HS. Regulation of HOXA-10 Expression by Testosterone in Vitro and in the Endometrium of Patients with Polycystic Ovary Syndrome. The Journal Of Clinical Endocrinology & Metabolism 2003, 88: 238-243. PMID: 12519859, DOI: 10.1210/jc.2002-021072.Peer-Reviewed Original ResearchConceptsPolycystic ovary syndromeOvary syndromeHOXA10 expressionEndometrium of patientsHOXA-10 expressionUterine HOXA10 expressionPregnancy loss rateReproductive-age womenAdverse reproductive outcomesExpression of HOXA10Ovarian androgensOvulatory disordersEndometrial biopsyEndometrial receptivityUterine dysfunctionAndrogen productionPregnancy rateReproductive outcomesTestosterone effectsHOXA10 mRNATestosteroneWomenEndometriumSyndromeHOXA10
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