Goals

• We hope to recruit 1,000 couples with RPL from 13 sites across the United States who remain without an explanation for their history of RPL after clinical evaluation.
• Whole genome sequencing (WGS) and other bioinformatic tests will be performed for research study participants.
• We expect to find disease-causing “typos” (pathogenic/likely pathogenic variants) in genes that are critical for fetal and placental development and a successful pregnancy.
• Ultimately, our findings may improve the clinical care of couples with a history of RPL.
• This research study is funded by the National Institutes of Health (NIH).

You may be eligible if:

• You are older than 18 years old.
• You recently experienced a pregnancy loss at < 20 weeks gestation.
• You have experienced two or more unexplained pregnancy losses in the past (in addition to your most recent pregnancy loss).
• Both biological parents of your most recent pregnancy loss are willing to participate.
• Your most recent pregnancy loss did not involve an egg and/or sperm donor.
• Your clinical evaluation for RPL has not revealed an explanation.

Participation in this Research Study Involves:

• A blood sample from both biological parents of your most recent pregnancy
• Access to your miscarriage sample(s)
• Access to your medical records
• Willingness to undergo additional clinical evaluation (if necessary) to determine your eligibility for this research study